STUDIES ON FORMULATION AND CHARACTERIZATION OF TOPICAL GEL CONTAINING MICROSPONGES OF MEFENAMIC ACID
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2018, Vol 4, Issue 2
Abstract
The objective of the present investigation was formulate & characterize the microsponge of mefenamic acid, these microsponges were prepared by quassi-emulsion method. Preformulation studies by FTIR, revealed no interaction between pure drug and the different polymers used. The prepared microsponges were characterized for their production yield, drug content, mean particle size & entrapment efficiency, Effect of formulation variable were also studied. The microsponge containing 0.5 gm of poly vinyl alcohol, 0.6 gm of ethyl cellulose and 5ml ethanol good were compared to the other formulation prepared The best microsponges (M3, M6, M9) in cooperated into gel. The topical gel was evaluated for their organoleptic characters, viscosity, spreadability, drug content and drug release studies. From that MG2 Shows better compared to other formulation. The various release kinetics were studied from that gel have the drug release seems to follow zero order kinetics as it is evidenced by correlation coefficients (r2=0.9907 to 0.9658) which is better than first order (r2 = 0.970 to 0.88) in mefenamic acid microsponge gel. Drug permeation from mefenamic acid gel followed Higuchi model or matrix diffusion.
Authors and Affiliations
Shuhaib B.
Keywords
Related Articles
- EP ID EP655135
- DOI -
- Views 152
- Downloads 0
3 D PRINTING TECHNOLOGY: A NEW ERA IN MEDICINE
Three dimensional printing may open up a whole new chapter of opportunities for pharmaceutical research and bio-technology applications. Three dimensional printing (3D) is a method to make three dimensional objects by fu...
BIOCHEMICAL ROLE OF ELECTROLYTE EXCRETION IN AMINOGLYCOSIDE NEPHROTOXICITY
Objective: To access the role of electrolyte excretion in aminoglycoside renal demage using experimental rats. Methods: Six groups each comprising five glycerol-pretreated and non-glycerol-pretreated rats were employed....
SURGICAL REPAIR OF OLD NEGLECTED CUT INJURY OF TENDUACHILLIES BY MUSCLE SLIDE
Background: Late presentation of cut injury of tendoachillis is very common in our part of the country and retraction of cut ends are a major problem. Methods: In the present series 11 cases of different age groups and b...
TRI-IMMUNOPHASIC THERAPY: A REVIEW
Periodontitis is a group of inflammatory diseases that affect the connective tissue attachment and supporting bone around the teeth. It is widely accepted that the initiation and the progression of periodontitis are depe...
ROLE OF ERANDADI TAILA IN THE MANAGEMENT OF KARNA NADA-A CONCEPTUAL STUDY
Karna Nada, a hearing disorder mentioned in Sushruta Samhita can be co-related with tinnitus on the basis of signs and symptoms. As per the literature, Karna Nada is Vata Dosha predominant disorder along with Avarana of...