STUDIES ON FORMULATION AND CHARACTERIZATION OF TOPICAL GEL CONTAINING MICROSPONGES OF MEFENAMIC ACID
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2018, Vol 4, Issue 2
Abstract
The objective of the present investigation was formulate & characterize the microsponge of mefenamic acid, these microsponges were prepared by quassi-emulsion method. Preformulation studies by FTIR, revealed no interaction between pure drug and the different polymers used. The prepared microsponges were characterized for their production yield, drug content, mean particle size & entrapment efficiency, Effect of formulation variable were also studied. The microsponge containing 0.5 gm of poly vinyl alcohol, 0.6 gm of ethyl cellulose and 5ml ethanol good were compared to the other formulation prepared The best microsponges (M3, M6, M9) in cooperated into gel. The topical gel was evaluated for their organoleptic characters, viscosity, spreadability, drug content and drug release studies. From that MG2 Shows better compared to other formulation. The various release kinetics were studied from that gel have the drug release seems to follow zero order kinetics as it is evidenced by correlation coefficients (r2=0.9907 to 0.9658) which is better than first order (r2 = 0.970 to 0.88) in mefenamic acid microsponge gel. Drug permeation from mefenamic acid gel followed Higuchi model or matrix diffusion.
Authors and Affiliations
Shuhaib B.
Keywords
Related Articles
- EP ID EP655135
- DOI -
- Views 149
- Downloads 0
THE CORRELATION BETWEEN ENERGY, PROTEIN, AND ZINK INTAKE AND HISTORY OF INFECTIOUS DISEASE WITH STUNTING CASE ON TODDLER IN TAMANSARISUB-DISTRICTS TASIKMALAYAIN 2016
Tamansari district is one of areas in Tasikmalaya that has health problem; it can be seen by prevalence of malnutrition and less nutrition are quite high with stunting prevalence on toddler of 13,17%. The aim of this stu...
ASSOCIATION OF APPETITE, FUNCTIONAL AND PSYCHOSOCIAL STATUS WITH THE MALNUTRITION AMONG ELDERLY RESIDING IN OLD AGE HOMES
Malnutrition is a common phenomenon among the elderly and quite often related to psychological and functional problems. The objective of this study was to determine malnutrition risk and its association with appetite, fu...
REVIEW: ECONOMIC VALUATION TECHNIQUES FOR CONSERVATION OF NATURAL RESOURCES AND WATERSHED MANAGEMENT
One of the objectives of conservation of natural resources is to strive for environmental sustainability for the benefit of the entire community. Achieving this goal means maximizing the total economic value of a conserv...
FORMULATING FAST DISINTEGRATING ZINC TABLET USING SINGLE STRUERS LABOPRESS-1
The purpose of our research work was to formulate tablets of zinc as a nutritious element by direct compression method employing different disintegrants and ascorbic acid as an antioxidant at different proportions in add...
TURBIDIMETRIC AS AN EFFICIENT SIGN OF WATER CHARACTERISTICS ALTERATION
The physico-chemical parameters of water samples collected from three sites of Varal Devi lake in Bhiwandi city were assessed. The physicochemical parameter like Turbidity were determined.This parameters were determined...