STUDIES ON OXIDATIVE STRESS MARKERS OF ALLOXAN INDUCED DIABETIC WISTAR RATS TREATED WITH TETRACARPIDIUM CONOPHORUM AND PIPER GUINEENSE (1:1 MIXTURE).
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 5
Abstract
This study was designed to investigate the glucose levels and markers of oxidative stress on alloxan- induced diabetic wistar rats treated with ethanolic leaf extracts of 1:1 mixture of Piper guineense (PG) and Tetracarpidium conophorum (TC). A total of thirty rats weighing between 100-150g were used for this study. They were divided into six (6) groups comprising Normal control (received distilled water), Negative control (received 100mg/kg body weight of alloxan), Positive control (2.5mg/kg body weight) and test groups which received 300mg/kg body weight of Ethanol Extract of P. guineense (EAPG2), Ethanol Extract of T. conophorum (EATC3), Ethanol Extract of P. guineense + T. conophorum in ratio1:1 (EAPGTC4). Diabetes was induced by intraperitoneal administration of 100mg/kg body weight of alloxan (A) for seven days. After treatment, the result showed that fasting blood glucose level in the test groups had significant (p<0.05) decrease when compared to the alloxan treated group only. Also, the oxidative stress markers indicated significant (p<0.05) decrease in malondialdehyde (MDA) and significant (p<0.05) increase in antioxidant enzymes superoxide dismutase (SOD), catalase( CAT) and reduced gluthatione (GSH) comparable to test groups. Histopathological examination of the pancreas and liver tissue showed recovering and good cellularity on the pancreas and liver tissues. From the findings of this study, it can be concluded that 300mg/kg body weight of P. guineense and T. conophorum (1:1 mixture) exhibited hypoglycemic and antioxidant potentials ameliorating damages brought about by alloxan.
Authors and Affiliations
Obomanu. F. G, Dokubo. A.
Keywords
Related Articles
- EP ID EP296030
- DOI 10.21474/IJAR01/7068
- Views 55
- Downloads 0
SPONTANEOUS RENAL ALLOGRAFT RUPTURE OF UNKNOWN ETIOLOGY: A CASE REPORT.
Introduction: Rupture of renal allograft is a rare but serious complication of transplantation. This is usually attributed to acute rejection, acute tubular necrosis, or renal vein thrombosis.Some other causes like renal...
EXPLORING MULTICULTURAL ASPECTS IN ZADIE SMITHS WHITE TEETH.
Zadie Smith made an astonishing debut novel White Teeth, published in 2000, when she was twenty four years old. She deals with many issue connected with living in a multicultural society and with the gap between the firs...
ROLE OF RASAYANA DRAVYA AND DIET AS PREVENTIVE MEDICINE IN VYADHI OF MAHASROTASA WITH SPECIAL REFERENCE TO GASTROINTESTINAL TRACT DISORDER: A CONCEPTUAL STUDY.
The aim of Ayurved is not only for treat the disease but also prevent it. Two types of treatment modalities are explained, one is SvasthasyaUrjaskara, in which drugs are given to prevent the disease, another is ArtasyaRo...
NETWORKING SKILLS OF PROGRAM IMPLEMENTERS AND THE QUALITY OF ORGANIZATIONAL LINKAGES IN SELECTED STATE UNIVERSITIES IN THE PHILIPPINES.
State colleges and universities (SUCs) in the Philippines established organizational linkages to better reach out to the communities. The SUCs entered into consortium contracts with other institutions to extend services...
A STUDY EVALUATING THE POSITION OF THE OCCLUSAL PLANE RELATIVE TO PAROTID PAPILLA IN KASHMIRI POPULATION.
Introduction: It is challenging for prosthodontist to reorient and relocate the lost occlusal plane in edentate patients. Several intraoral landmarks that help in re-orienting and relocating the lost occlusal plane. Aims...