Study Comparing Ramosetron, Granisetron and Ondansetron in Laparoscopic Surgeries Under General Anaesthesia
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 7
Abstract
Backgound: Postoperative nausea and vomiting (PONV) is one of the most common and distressing complications after anaesthesia and surgery. Aim: Compare the antiemetic efficacy of intravenous Ramosetron, Granisetron and Ondansetron for prophylaxis of post operative nausea and vomiting after laparoscopic surgeries under General Anesthesia. Methodology: It is a prospective study include 50 patients undergoing laproscopic surgery under general anesthesia. Study is done for a period of 6 months. Patients were randomly divided into three groups, Group-A received Ondansetron 8mg, Group-B received Granisetron 3 mg and Group-C received Ramosetron 0.3mg Results: However, there were no significant differences in the incidence of nausea and vomiting, severity of nausea, and required rescue PONV between the groups in first 24 hours. Between 24-48 hrs the incidence of nausea and vomiting is significantly(p value=0.05) less in Group C compared to group-A. Ramosetron is giving longer protection against PONV up to 48 hours. Conclusion: Study therefore concludes that prophylactic therapy with Ramosetron is more effective than with Ondansetron and Granisetron for the long term prevention of PONV after laparoscopic surgeries under general anaesthesia
Authors and Affiliations
G. Harinath
Keywords
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