Study of a prescribing pattern of empirical antibiotics in patients with sepsis in a tertiary care hospital of Eastern India
Journal Title: International Journal of Medical Research and Review - Year 2016, Vol 4, Issue 11
Abstract
Background: Blood stream infections cause significant morbidity and mortality worldwide. Rational use of antimicrobials is required for proper management. Appropriate selection of empirical antibiotic therapy for diagnosed sepsis is difficult. Objective: The main objective of this study is to evaluate the prescribing pattern of antibiotics in patients with sepsis in a tertiary care hospital of Eastern India. Methods: The study was carried over a period of one year at the Department Of Medicine, Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar. We studied 100 patients with sepsis regarding empirical antibiotics prescribed on initial evaluation. Results: As per the prescription analysis, the antibiotics used as empirical treatment based on class were penicillin derivatives (72%), macrolide (40%), nitroimidazole (40%), Cephalosporin (28%), fluoroquinolones (18%), aminoglycoside (13%), Carbapenems (3%) and oxazolidinone (4%). 56% patients received a combination of two antibiotics. We had seen improvement in 86% of the patients and discharged them. The rest were either shifted to the specialty care or left the hospital against medical advice. Conclusion: This study found that beta-lactam antibiotics like piperacillin, amoxyclav and cephalosporins are mostly used in the empirical treatment of sepsis. Early initiation of antibiotics is associated with improved outcomes in severe sepsis and septic shock. The addition of two or more antibiotics increases the coverage especially of Gram-negative bacteria.
Authors and Affiliations
Lalatendu Mohanty, Debananda Sahoo, S. S. Panda, S Patro
Keywords
Related Articles
- EP ID EP231597
- DOI 10.17511
- Views 125
- Downloads 0
Clinical profile and comparison of SAAG with ascites fluid total protein (AFTP) in cases of ascites at a tertiary referral hospital in Maharashtra
Aims: This observational prospective study was carried out with aims of 1) study various presentations and clinical features in ascites cases, 2) assess different etiological factors, 3) compare serum ascitic albumin gra...
A clinical study of the effects of cilnidipine and amlodipine in hypertensive patient focusing on pedal edema
Introduction: Many Calcium channel blocker drugs for control of hypertension are available. New drug Cilinidipine is available and approved for treatment of hypertension. It acts by blocking both L-type and N-type voltag...
Inhibitory effects of copper on bacterial and fungal growth
Introduction: Researchers conducted a literature, technology and patent search that traced the history of understanding the “bacteriostatic and sanitizing properties of copper and copper alloy surfaces” which demonstrate...
Clinical profile of lung cancer in rural medical college of Maharashtra (India): a prospective study of three years
Aim: To Study the clinical, radiological & histological profile of lung cancer. Meterial & Methods: 94 patients who presented with cough, haemoptysis, chest pain, breathelessness, and having radiological features consist...
Clinical study of benign lesions of larynx
Aim of Study: To analyze over a period of 2 years, the demographics such as age, sex, distribution, occupation, the site of involvement, symptomatology and prognosis of the most frequent benign lesions of larynx. Materia...