STUDY OF AETIOLOGY AND CLINICAL FEATURES OF FEBRILE THROMBOCYTOPENIA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 87
Abstract
BACKGROUND Febrile thrombocytopenia is one of the most challenging problems in the field of medicine. Fever with thrombocytopenia is the common manifestation of infective diseases. It helps to narrow the differential diagnosis and management. Treatment of underlying condition will lead to rapid improvement in platelet count and minimise bleeding manifestations and other complications. Hence, there is a need for study to know the aetiology and clinical features of febrile thrombocytopenia. The aim of this study is to study the aetiology and clinical features of febrile thrombocytopenia. MATERIALS AND METHODS 50 patients who were admitted with febrile thrombocytopenia over 2 months of period from July 20th to 20th September 2017 in King George Hospital, AMC, Visakhapatnam, were studied retrospectively. RESULTS In this present study, the incidence of febrile thrombocytopenia was more common in male (66%) as compared to female (34%). The study reveals that age up to 50 years constituting 78% of the cases and above 50 years constituting 22% only. Apart from fever (100%) in male patients vomiting (28%) and cough (20%) were the most common clinical features, while in female patients, body pains (20%) and headache (18%). Bleeding manifestations were more common in males (18%) than in females (10%). Malaria in 22 cases (44%) constitutes the most common aetiology of febrile thrombocytopenia of which falciparum 10 (20%), vivax 8 (16%) and both 4 (8%) followed by viral infection including dengue in 17 cases (34%). The present study reveals that severe thrombocytopenia (platelets < 20000/mm3) is present in 18% of cases, moderate (20000 - 50000/mm3) in 34% and mild thrombocytopenia (> 50000/mm3) is present in 48% of cases. Melena was the most common presenting manifestation followed by petechiae and haematochezia. CONCLUSION Though there is no absolute relation between platelet count and severity of bleeding, the risk of bleeding increases as the platelet levels fall below 20,000/μL. In majority of the cases thrombocytopenia was asymptomatic, but in a significant number of cases bleeding manifestations are seen which require prompt management to prevent life-threatening complications.
Authors and Affiliations
Vasavilatha G, Ravi Kumar N, Suresh Kumar P
Keywords
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- EP ID EP277664
- DOI 10.14260/jemds/2017/1310
- Views 95
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