Study of AgNOR Value and MIB-1 in Breast Cancer Treated With Surgery
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2012, Vol 1, Issue 3
Abstract
AgNOR and MIB-1 are marker for breast cancer cell proliferation and can be use as based for radiotherapy treatment after surgery. Value of AgNOR and MIB-1 index were determined using staining and immunohistochemistry staining method respectively from 25 of microscopic slides of breast cancer tissue patients with surgery, and grouped based on degree of differentiation, 3 slides were good degree (G1), 16 slides were medium degree (G2) and 6 slides were poor degree (between G2 and G3). The result shown that the value of AgNOR and MIB-1 index were tended to increase with the increased differentiation degree. There was a positive correlation between the value of AgNOR and index of MIB-1 in all group of differentiation degree (r = 0.21), there is a negative correlation between AgNOR and MIB-1 on G1 (r =-0,97), positive correlation in G2 (r = 0.36) as well as positive correlation between G2 and G3 (r = 0.33). The positive correlation between AgNOR and MIB-1 were associated to the increased of G1, S and G2 phase in the proliferation cell and an increase of cells undergoing mitosis. The negative correlation were caused by the different cell proportion in G1, S and G2 phase, and undergoing mitotis.
Authors and Affiliations
Iin Kurnia, Esti Soetrisno, Erwin D. Yulian, Irwan Ramli, Zubaidah Alatas
Keywords
Related Articles
- EP ID EP334236
- DOI -
- Views 127
- Downloads 0
Study of Pre and Post Supplementation Green Tea Extracts to MDA Levels
High intensity exercise (HI) induces oxidative stress. Running for 2400 meters is one of the simple exercise form which can be counted as HI. During HI, increase of oxygen consumption happened in muscle cell resulted in...
N-MID Osteocalcin (N-MID Oc) and β-Crosslaps (β-CTx) as Biochemical Markers of Bone Turnover in Menopausal Women
Osteocalcin is a marker compound for bone formation while the β-crosslaps a fragment split from collagen type 1. The aims of this study were to determined of the value of N-MID osteocalcin (N-MID Oc) and β-CTx as a bio...
Influence of Antidiabetic Herbal Medicine to a Decrease Blood Glucose Levels of Diabetes Mellitus Patients at The ‘Hortus Medicus’ Scientification of Jamu Clinic Tawangmangu, Karanganyar
Diabetes mellitus (DM) was an annual disease characterized by parennials of blood glucose levels exceeding normal and impaired metabolism of carbohydrates, fat and protein caused by defficiency of insulin hormone relativ...
Clinical Pharmacist Roles On End-Stage Renal Disease Patient with Hemodialysis
End-stage renal disease with hemodialysis are considered as a multipathology and multitherapy patients which has an increase of morbidity and mortality rate. This research aim was to understand the roles of Indonesia cli...
Efficacy of Bacillus clausii and Saccharomyces boulardii in Treatment of Acute Rotaviral Diarrhea in Pediatric Patients
Abstract Diarrhea disease is considered as major health problem in developing countries. Rotavirus is the most common identifiable viral cause of diarrhea in all children and belongs to Reoviridae family. Rotavirus infec...