Study of Association of Lipoprotein (A) Levels with Carotid Atherosclerosis in Young Patients with Ischemic Stroke
Journal Title: International Journal of Neurology and Neurosurgery - Year 2018, Vol 10, Issue 4
Abstract
Context: Lipoprotein (a) is an established risk factor for coronary artery disease but its role as a risk factor for stroke is not established. Aims: To estimate the prevalence of elevated levels of lipoprotein (a) in young patients (18-55 years) with ischemic stroke and to study the association between lipoprotein (a) plasma concentration and carotid atherosclerosis Settings and Design: This observational, cross-sectional, single center study was conductedon 90 young (18-55 years) patients with imaging confirmed ischemic stroke for a duration of 1 year. Lipoprotein (a) samples were taken within 24 hours of presentation to the hospital and values >30mg/dL were considered abnormal. Carotid Doppler was done by a cardiologist unaware of history of patientsl. Patients were divided into two groups: Group A (normal) and Group B (abnormal). Average values of lipoprotein (a) levels in both the groups were taken and compared using appropriate statistical analysis. Results: There were 65 males and 25 females in the study. Prevalence of elevated lipoprotein (a) in the study population was found to be 44.4%. It was more than the other traditional risk factors for stroke. Prevalence of carotid atherosclerosis and carotid stenosis in the study was 41.1% and 31.1% respectively. Elevation of lipoprotein (a) was strongly associated with carotid atherosclerosis (p=0.001). Mean values of lipoprotein (a) were statistically higher in the atherosclerosis group than in no atherosclerosis group (p=0.002). Lipoprotein (a) was positively associated with carotid stenosis in a graded manner but its association with CIMT was not significant. The association of lipoprotein (a) and carotid atherosclerosis was independent of other risk factors.Conclusion: Lipoprotein (a) is strongly associated with carotid atherosclerosis (especially carotid stenosis) in young patients with ischemic stroke and the association is independent of the traditional risk factors.
Authors and Affiliations
Pooja Gupta
Keywords
Related Articles
- EP ID EP562941
- DOI 10.21088/ijnns.0975.0223.10418.7
- Views 55
- Downloads 0
The Hidden Hematoma of the Head: Analysis of Vertex EDHs and their Outcome
Context: The skull vertex is an uncommon site for epidural hematoma (EDH) formation. The usual cause of a hematoma is a tear in the sagittal sinus due to trauma or saggital suture diastasis. Vertex EDH, even of small vol...
Unilateral Cerebellar Aplasia in Adult–A Rare Incidental Finding
Unilateral cerebellar aplasia is a very rare developmental disorder usually most commonly seen in children after a prenatal insult. It hasmultifarious clinical presentations ranging from development delay to ataxia and c...
Diffuse Axonal Injury: An institute Experience
Introduction: Traumatic Brain Injuries are among the leading cause of mortality and morbidity world over. They are the leading cause of death among the younger age groups accounting for several indirect social and econom...
A Rare Case Report of Frontotemporal Oligodendroglioma with Extraneural Orbitoethmoidal Invasion: Its Current Implications
Oligodendrogliomas generally remain confined to the nervous parenchyma throughout their entire course. However, there are exceptionally rare cases, which show either transdural extension or extraneural spread. In reviewi...
Management of Tuberculosis Spine: Our Institute Experience
Background: Tuberculosis is a very common disease affecting the impoverished and is a source of morbidity causing significant burden to the society. Involvement of the spine is fairly common and it causes significant dis...