STUDY OF BIOMEDICAL EFFICACY OF BETA ASARONE AGAINST PANCREATITIS RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 9
Abstract
Albino Wistar rats were divided into IV groups. Group I served as normal and II as negative control which receives normal diet containing 5% fat. Group III and IV rats were treatment groups administered orally with β-asarone 25mg and 50mg/kg body weight/day and also fed with high fat diet containing 25% fat respectively at the last 28 days of the experimental period. Group II-IV were administered with 50µg/kg colchicine interaperitonially to induced acute pancreatitis. Group II rats received 50 µg/kg colchicine. Serum lipase, amylase, cytokine IL-1β, myeloperoxidase activity and antioxidant status in pancreas were assessed. We observed a significant decrease in the activity of serum amylase, lipase, IL-1β B asarone supplementation was found to maintain the activity of myeloperoxidase and antioxidants in pancreas. The optimum protective effect was observed in rats received 50 mg/kg body weight of beta asarone and the histopathological observations added more evidence for our results.
Authors and Affiliations
Ravichandiran Velayutham , Vishal Patil , Shanmugarajan T. S
Keywords
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- EP ID EP158941
- DOI 10.7897/2230-8407.069133
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