Study of bone markers in hyperthyroidism: Single centre experience from south India

Journal Title: Journal of Medical and Scientific Research - Year 2015, Vol 3, Issue 2

Abstract

Aim: To evaluate bone health markers and vitamin D status in patients with hyperthyroidism comprehensively, and comparison of same with matched controls. Materials and methods: The study has been done on 30 newly diagnosed hyperthyroid patients and matched controls. Cases were selected after careful exclusion of conditions which adversely affect bone health. Statistical comparisons were performed with Student’s t test. Results: The study group has shown normal calcium (20% had hypocalcemia), normal phosphorus, normal PTH values, raised alkaline phosphatase levels & significant rise in both bone formation (Osteocalcin) and resorption (β-cross laps) markers (P<0.05). In addition 95% of our subjects (patients and controls) were vitamin D deficient (mean-17.2 ng/dl). There is no specific increase in vitamin D deficiency in hyperthyroidism patients. Conclusion: Hyperthyroidism is associated with increased rate of bone remodeling & changes in mineral homeostasis, thereby increases risk of fractures. Associated vitamin D deficiency further deteriorates bone quality. So it is suggested therapeutic vitamin D and calcium supplementation in addition to antithyroid medication.

Authors and Affiliations

Babulreddy H, Mounika G, Rakesh S, Ramesh J, Nagesh S

Keywords

Related Articles

Sutureless and glue-free technique of conjunctival autograft in primary pterygium surgery: A series of 52 eyes

Purpose: To study the efficacy and complications of sutureless and glue free conjunctival autograft for the management of primary pterygium over a period of one year. Methods: This was a retrospective case series and pa...

Imaging spectrum in Brodie’s abscess

Abstract is not available for this article

Enhancement of paclitaxel and doxorubicin cytotoxicity in breast cancer cell lines in combination with piperine treatment and analysis of expression of autophagy and apoptosis genes

Background: Breast cancer treatment failure mainly attributed to drug resistance and suboptimal dosage of drugs reaching to the actual target. Several Bioenhancers have been used for enhancing drug availability to the ta...

Placenta percreta

Abstract is not available for this article

Haemophilic arthropathy

Acquired haemophilia (AH) is extremely rare and potentially fatal bleeding disorder and it is associated with significant morbidity and mortality rate between 7.9% to 22%. Upto 90% of people with AH experience bleeding....

Download PDF file
  • EP ID EP606282
  • DOI 10.17727/JMSR.2015/3-010
  • Views 74
  • Downloads 0

How To Cite

Babulreddy H, Mounika G, Rakesh S, Ramesh J, Nagesh S (2015). Study of bone markers in hyperthyroidism: Single centre experience from south India. Journal of Medical and Scientific Research, 3(2), 53-56. https://europub.co.uk/articles/-A-606282