Study of Candida Bloodstream Infections in Surgical Intensive Care Unit Patients and Susceptibility Profile of the Isolates
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2015, Vol 4, Issue 3
Abstract
Background: The increased incidence of fungal infections in the past two decades has been overwhelming. Despite the fact that invasive fungal infections are still under-diagnosed and underreported, bloodstream infection due to Candida is now being recognized as an important public health problem especially in ICU patients with considerable morbidity, mortality and health care costs. Objective: To study the incidence, risk factors and antifungal susceptibility of Candida bloodstream infection in our hospital. Material and Methods: In the present study, the blood samples were collected from patients admitted in Surgical ICU. Samples were processed and antifungal susceptibility of the isolates was performed using standard protocol. Results: Out of total 93 patients, 14 (15.05%) were positive for candidemia with equal distribution of both C. albicans and nonalbicans Candida spp. The risk factors associated with candidemia showing statistical significance were length of ICU stay > 7 days, mechanical ventilation, central venous catheters and uncontrolled diabetes. Among the patients with candidemia the mortality rate was 78.57 %. Resistance to Amphotericin B was seen in 33.33 % isolates of C. tropicalis and 100 % isolates of C. rugosa. 33.33 % of C. tropicalis and 50 % of C. rugosa showed dose dependent susceptibility to Fluconazole. Conclusion: Early diagnosis and antifungal susceptibility testing is very important in the treatment of candidemia for reducing the mortality rate.
Authors and Affiliations
Vijaya S. Rajmane , Shivkumar T. Rajmane , Shivaji T. Mohite , Vinayak V. Raje
Keywords
Related Articles
- EP ID EP142945
- DOI -
- Views 96
- Downloads 0
Quality of Life in Geriatric Population in a Community Development Block of Kishanganj, Bihar, India
Background: Ageing universally affects individual, family, community and society with reduction in quality of life on chronologic, biological, social, and psychological dimensions. Aim and Objectives: The study was done...
Pulmonary Talco-silicosis in a Balloon Making Industry Worker
We report a case of a thirty eight year old lady, working in balloon making industry. She was referred to us in view of incidental chest X-ray changes found during preoperative pulmonary evaluation. She was asymptomatic...
Xanthogranulomatous Oophoritis- A Rare Inflammatory Lesion
Xanthogranulomatous inflammation is a specialform of chronic inflammation that is destructiveof affected organ. Xanthogranulomatous inflammationof ovary and fallopian tube is an uncommonentity and it is usually known to...
Phaeohyphomycosis Masquerading As Epidermal Cyst – A Diagnostic Dilemma in Immunocompetent Hosts and Review of Literature
Phaeohyphomycosis is caused by a rare dematiaceous, pigmented, mycelia forming fungi. It is an opportunistic fungal infection in immunocompromised hosts. It can present with varied clinical manifestations, as subcutaneou...
Current Status of Knowledge, Attitudes and Practices towards HealthcareEthics among Doctors and Nurses from Northern India - A Multicentre Study
Background: Recent raise in litigation againsthealthcare practitioners is definitely an issueof immediate concern and may reflect an increasein unethical practices by them. Professionalrelations between physicians and nu...