STUDY OF CD163 AND B2M AS MARKERS FOR HODGKIN LYMPHOMA IN HUMAN AND ITS RELATION WITH CLINICO–PATHOLOGICAL BEHAVIOR
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 4
Abstract
Background: Hodgkin lymphoma is the most non malignancies at young adult ages, and is a curable disease in most patients. In the present study, our suggestion is to use CD163 and B2M as supplementary markers for the prognosis concerning Hodgkin lymphoma. So, identification of sensitive biomarkers to improve the prognosis related Hodgkin lymphoma is needed. Aim of the work: The aim of present study was to discuss the prognosis utility of serum CD163 and serum B2M in patients for Hodgkin lymphoma during and post therapy the clinical advantage of these markers will be decreased or normal during or post therapy. CD163 will be compared with B2M which is a routinely marker used for diagnosis and in follow up the patients for Hodgkin lymphoma. Results: Serum CD163 was significantly in most patients for Hodgkin lymphoma. The receiver operating characteristic curve (ROC) showed the best cut off values for CD163 and B2M were 5.0 ng/ml and 2.50 mg/l respectively. Area under the curve of CD163 and B2M were significantly 0.79 and 0.78. The sensitivity of CD163 and B2M were 76.7% and 66.7% respectively. Conclusion: Results revealed that serum CD163 may be used as potential prognostic markers for Hodgkin lymphoma patients.
Authors and Affiliations
Hossam Darwish
Keywords
Related Articles
- EP ID EP636032
- DOI -
- Views 122
- Downloads 0
A RANDOMIZED, MULTIPLE-DOSE, MULTICENTER, COMPARATIVE PARALLEL STUDY TO EVALUATE THE PHARMACOKINETIC CHARACTERISTICS OF INTRAVENOUS INFUSION OF RITUXIMAB (HETERO) AND REFERENCE MEDICINAL PRODUCT (RITUXIMAB, ROCHE) IN INDIAN PATIENTS OF NON-HODGKIN'S LYMPHOMA
Aim: To evaluate the pharmacokinetic characteristics of two formulations of Rituximab (test and reference) at 1st & 6th cycles (steady state) of chemotherapy. Methods: A total of 135 Diffuse Large B-cell Lymphoma (DLBCL)...
HEALTH PROBLEMS AND MEDICATION SELF- MANAGEMENT AMONG UNIVERSITY STUDENTS IN THE UAE
Aim: This study aims to look at the most common health problems existing among students & what could contribute to worsen their health status. Then, to investigate the prevalence of self-medication, its risk factors & to...
SOCIAL MEDIA IMPACT ON PROFESSIONAL AND PROFILE LEVELS OF DENTAL STUDENTS AND INTERNS IN SAUDI ARABIA
Backgrounds: Social networking is a web-based channel that people use to communicate with one another and express their thoughts, opinions and experiences. The Internet and social media are the most effective communicati...
OXIDATIVE STRESS AND SOME INFLAMMATORY BIOMARKERS IN PATIENTS WITH CORONARY HEART DISEASE
Myeloperoxidase is a marker of oxidative stress and is released after neutrophils Energizing.It has potent pro-oxidative and proinflammatory properties. This study was objectives toinvestigate theimpactof myeloperoxidasea...
HYPERTRIGLYCERIDAEMIA INDUCED ACUTE PANCREATITIS IN AN INFANT: A CASE REPORT
Hypertriglyceridaemia is a rare cause of acute pancreatitis in children, which requires a high index of clinical suspicion. We report a case of a 6-month-old male infant who presented to the emergency department with the...