Study of Clinical-Etiological Profile of Macrocytic Anemia and Correlation of Serum Vitamin B12 & folate level with Mean Corpuscular Volume (MCV)
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 6
Abstract
Introduction: Macrocytic anemia is a group of diverse disorders and so it demands further clinical and laboratory assessment .This study was conducted to study the clinical and laboratory parameters of patients with macrocytic anemia and its etiology. Materials and methods: This study was a cross-sectional retrospective study, done on 216 adult patients with macrocytic anemia. Macrocytic anemia was defined when peripheral blood examination showed anemia with a mean red blood corpuscular volume of >100 fl. After inclusion patients were subjected to various investigations to find out etiology of macrocytosis. Result: The most common cause of macrocytic anemia was megaloblastic anemia (34.8%). The major causes of non-megaloblastic macrocytic anemia (65.2%) were alcoholism & alcoholic liver diseases (28.7%) primary bone marrow disorders (22.7%), and hemolytic anemia (5.6%). The megaloblastic anemia observed was due to vitamin B12 deficiency (54%), folic acid deficiency (25.6%) and combined B12 and folate deficiency (20.4%). We found no significant association of vitamin B12 level and folic acid with MCV value. Conclusion: Systematic evaluation of macrocytosis is needed to distinguish megaloblastic and non – megaloblastic causes of macrocytosis. Megaloblastic anemia due to Vitamin B 12 or folate deficiency remains the most important cause of macrocytic anemia.
Authors and Affiliations
Dr. Naresh Kumar
Keywords
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