Study of Clinical Features, Laboratory Investigations and Radiological Findings of Gall Bladder Diseases

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Study of Clinical Features, Laboratory Investigations and Radiological Findings of Gall Bladder Diseases

Journal Title: National Journal of Laboratory Medicine - Year 2019, Vol 8, Issue 1

Abstract

ABSTRACT Introduction: Clinical diagnosis of the gall bladder diseases is made, based on history and physical examination along with laboratory and radiological findings. Correlation of clinical findings, with laboratory findings and radiological findings is necessary to make correct diagnosis of gall bladder diseases excluding other causes of right hypochondrial pain as well as to determine appropriate mode of treatment in different gall bladder diseases. Aim: To study clinical features of gall bladder diseases and correlating it with laboratory investigations and radiological findings. Materials and Methods: The present study includes prospective cases of two years from June 2015 to May 2017 and also includes cases from retrospective archival of data of two and half years i.e., Jan 2013 to May 2015. Thus, it includes 130 cases of cholecystectomy specimens during Jan 2013 to June 2017. Results: The commonest symptom was abdominal pain (100%), followed by vomiting (78%) and fever (8.5%). Higher values of total leucocyte count, Serum alkaline phosphatase (>140 IU/mL), Serum aspartate aminotransferase (AST) (>40 IU/L), and Serum Alanine aminotransferase (ALT) (>45 U/L) were observed in cholecystectomy patients. Ultrasonography successfully detected cases of chronic cholecystitis and acute cholecystitis but out of total four cases of gall bladder adenocarcinoma, ultrasonography diagnosed malignancy in only two cases. Conclusion: Clinical presentation of diseases of gall bladder is vague. Even malignancy of gall bladder presents late in the course and with nonspecific symptoms, which can misguide the clinicians. Findings of malignancy were subtle on radiological examinations also. Diagnosis of malignancy was made only by histopathological examination. So Clinical diagnosis of the gall bladder diseases should be supported by relevant laboratory and radiological findings. Correlation of clinical findings, with laboratory findings and radiological findings is necessary to make correct diagnosis of gall bladder diseases as well as to determine appropriate mode of treatment in different gall bladder diseases.

Authors and Affiliations

Cyrus Dara Jokhi, Sujata R Kanetkar, Nikita Vinod Vohra

Keywords

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EP ID EP609994
DOI 10.7860/NJLM/2019/37697:2328
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