Study of Collagen in the Urethral Plate of Children with Hypospadias
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
Aims & Objectives – The study was performed to quantify the amount of Collagen in the Urethral Plate of Children with Hypospadias. Masson trichrome stain (MT) was compared with picrosirius red stain (PSR) and their outcomes. Materials & Methods – The study was performed in 25 children (age 1 year to 12 years). After TIP procedure, biopsy was taken from the Urethral plate. The tissue was subjected to MT and PSR staining, and correlated with post-operative status at 15 days, 1 month and 3 months. Result:- MT score versus PSR score was correlated. MT score ranged from 1- to 3+ and PSR score ranged from 1- to 3+. The post-operative outcomes at 2 week, 01 month & 03 months had insignificant p-value with PSR score. The position of neourethra and Residual Chordee were found to be significant with p-value = 0.05. The sensitivity of PSR scores with MT score as gold standard was 56.25% with 95% CI of 29.88% to 80.25%. Conclusion: - Residual chordee was present more in proximal hypospadias as found by both MT and PSR leading to poorer outcome. Distal hypospadias had good result with both MT & PSR stains using fluorescent polarizing microscopy.
Authors and Affiliations
Shyam Sundar Sahu, Amita Sen, Minakshi Bhardwaj
Keywords
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- EP ID EP406729
- DOI 10.9790/0853-1710124551.
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