Study of comparative effect of hydroxychloroquine and vildagliptin on glycaemic efficacy and HbA1cin type 2 diabetes patients who were inadequately controlled with metformin and glimepiride dual therapy
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 4
Abstract
Objective: The objective of this study is investigate the glycaemic efficacy parameters of hydroxychloroquine (HCQ) in comparison to those of vildagliptin in uncontrolled type 2 diabetes mellitus (T2DM) patients who were inadequately controlled with metformin and glimepiride dual therapy. Methods: Uncontrolled type 2 diabetes patients with glycated haemoglobin (HbA1c) of 7.0–9.0% and on metformin up to 1000 mg/day along with glimepiride up to 2 mg/day were selected for the study. Hundred eligible patients were randomly divided into two groups. One group comprises of 50 patients whose baseline fasting plasma glucose (FPG), post prandial plasma glucose (PPPG), HbA1c were determined and the patients were put on hydroxychloroquine 400 mg per day apart from metformin 1gm /day and glimepiride 2mg/day, another group comprises of 50 patients whose baseline FPG, PPPG, HbA1c were determined and put on vildagliptin 100 mg per day apart from metformin 1gm /day and glimepiride 2mg/day. At 3 months and 6 months, levels of glycaemic parameters were compared with those at baseline. Results: At 3 months, while similar reductions of glycated hemoglobin (HbA1c) levels were observed with these two drugs, after 24 weeks of treatment with hydroxychloroquine 400mg, metformin and glimepiride, subjects had greater reduction in FPG, PPPG and HbA1c as compared to vildagliptin, glimepiride and metformin. Conclusion: This study showed that hydroxychloroquine can be an effective alternative to DPP4 inhibitors like vildagliptin for add on therapy to the patients who are inadequately controlled with metformin and glimepiride dual therapy
Authors and Affiliations
Arjun Baidya
Keywords
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