Study of comparative evaluation of Atorvastatin and Salacinol (Salacia roxburghii) on BMI, lipid profile and adiponectin level in diabetic and non-diabetic patient of chronic kidney disease with hypertension
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 11
Abstract
Most of the newer concepts in Nephrology developed in the 19th and 20th century. At the beginning of this century even the term Nephrology did not exist. Progression of renal failure is an area of Nephrology where our understanding has improved appreciably in the last century but still our knowledge is like a drop in ocean. We have ample of evidence that progression of renal failure can be slowed down but we still need more definite information whether established renal failure can be reversed. Retarding the progression of renal failure is one of the most important task for the nephrologists as it not only improves the quality of life of the patient but also delays the development of end stage renal disease. This pilot clinical study was planned to explore the therapeutic potential of Salacinol in retardation of chronic kidney disease progression and anti-atherosclerotic property by looking for if reduction in CIMT is possible. Objectives: To Study of comparative evaluation of atorvastatin and Salacinol (Salacia roxburghii) on BMI, Lipid profile and Adiponectin level in Diabetic and non-diabetic patient of chronic kidney disease with hypertension Methods: The present study was conducted in the Department of General medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi. Eighty patients of mild to moderate stable chronic renal failure with hypertension attending Nephrology OPD or admitted in Nephrology ward from May 2014 to June 2015 were included in the study. Patient with acute MI, congestive heart failure, unstable angina, myopathy. Non-compliant patient & those patient taking medicines for their disease which is known to improve lipid profile (lipid lowering agent other than atorvastatin) were excluded from the study. Subsequently patients were allocated to one of the two groups, the first group consisted of Diabetic patient treated with atorvastatin Salacinol and second group was of nondiabetic treated patients. Results: Among total patients included in the study 35 were non diabetic and 45 were diabetic. On BMI comparison in diabetic & non-diabetic at the end of study, changes were found to be highly significant suggesting probably role of Salacinol as weight lowering agent. Mean LDL/ HDL ration in diabetic and non-diabetic at baseline were 4.61±0.49 and 4.49±0.59 and on intergroup comparison changes were statistically significant at three and six months. Mean cholesterol changes when compared diabetic & non-diabetic group were statistically insignificant at the end of study. Mean triglyceride level in diabetic & non-diabetic at baseline were 167.6±18.6 & 167.6±14.8 and on comparison with each other changes were statistically significant at six months. Mean adiponectin value at baseline in diabetic and non-diabetic were 5.32±1.53 and 4.22±1.58 and changes were statistically significant at 3 and 6 months in diabetic group and at 6 months in non-diabetic group. On Intergroup comparison changes were statistically significant at 3 and 6 months. However, changes were statistically significant even at baseline. Conclusion: The male patients dominated over the female patients with a male to female ratio of 2:1. Age of the patient ranged from 20yrs onward. Majority of the patient were above 40yrs of age. Commonest symptom was weakness in all the groups followed by anorexia, swelling over body, pallor & sleep disorders. No significant effect of the drug was seen on 24hrs urinary protein, blood pressure, hemoglobin & GFR. In patient treated with Atorvastatin and Salacinol, the changes in Adiponectin level were statistically significant (<().()()l) at three and six months. On comparison of non-diabetic and diabetic significant decrease (<0.05) including BMI, LDL/ HDL ratio, triglyceride level were observed at the end of study.
Authors and Affiliations
Dr. Manish Kumar Bhaskar, Dr. RG Singh
Keywords
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