Study of Comparison of Serum Lipid Profile, Electrocardiographical & Echocardiographical changes between Euthyroid Diabetic & Hypothyroid Diabetic patients in a tertiary care hospital, Kolkata
Journal Title: National Journal of Medical Research - Year 2017, Vol 7, Issue 2
Abstract
Introduction: Insulin and thyroid hormone metabolism and functions are dependent on each other. But the presence of hypothyroidism in type 2 diabetes mellitus patients and its impact on cardiovascular system are a less explored area. Aim: To compare the serum lipid profile, Electrocardiogrpathy & Echocardiographical changes between Euthyroid diabetic & hypothyroid diabetic patient and to document the difference in cardiovascular complications between these two groups. Methodology: A cross-sectional observational study conducted on 100 Type 2 Diabetes Mellitus patients who were divided into euthyroid and hypothyroid diabetic group and were subjected to tests for dyslipedemia (Total Cholesterol, Triglyceride, HDL-C and LDL – C) and cardiological dysfunction using ECG and Echocardiography and the results were compared. Results: 31% diabetic patients were hypothyroid and their mean cholesterol , triglyceride , Low density lipoprotein were 239.03 mg/dl , 181.35 mg/dl and 171.74 mg /dl respectively and hence found to be significantly increased as compared to euthyroid diabetic patients. In ECG, hypothyroid diabetic patients showed sinus bradycardia ( 32.6%) , low QRS voltage (19.35%) and increased QTc interval ( 16.13%). In Echocardiography , 9.68 % and 58.06 % hypothyroid diabetic patients had grade 2 and grade 1 diastolic dysfunction respectively with significant correlation. Conclusion: Dyslipidemia with cardiological dysfunction is found to be more prevalent in hypothyroid (including subclinical hypothyroid) diabetes mellitus patients with significant association as compared to euthyroid diabetic patients.
Authors and Affiliations
Soumya Sarathi Mondal, Anwesha Pan, Animesh Maity, Subhas Bhuin, Snigdhendu Pal, Pinaki Nath
Keywords
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