Study of Corpus Luteum Function in Infertile Women by Timed Endometrial Biopsy and Progesterone Assay in the Diagnosis of Luteal Phase Defect
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 8
Abstract
Luteal phase defect is an improper development of endometrium for nidation, either due to decreased secretion of progesterone by the corpus luteum or when the effect of progesterone is limited at the endometrium. Both primary infertility and recurrent abortions have been found associated with this defect, however the diagnosis is difficult as there are no defined criteria for diagnosis. Aim of the study was to evaluate corpus luteum function in infertile women by timed endometrial biopsy and progesterone assay in the diagnosis of luteal phase defect. Cross sectional prospective study. Fifty infertile women with regular periods and a normal menstrual flow were included. The patients were evaluated by midluteal endometrial biopsy and serum progesterone. The tests were done on the same day in each patient, in the mid luteal phase. Delay of more than 2 days was taken as luteal phase defect. Age matched, fertile, normally menstruating women were taken as controls. Result: 44 patients were within two days of the chronological dating. 6 endometria were dated as more than two days short of the chronological date. Four cases showed coordinated delay and 2 cases showed dissociated delay. Six endometria showed proliferative phase endometrium. Mean progesterone level of 6.8+ 1.75 ng/ml was found in patients of luteal phase defect. Conclusion: Endometrial biopsy specimen provides an accurate measure of quantitative progesterone effect on corpus luteum function and also of the response of endometrium to the steroid stimuli and therefore is recommended for the diagnosis of luteal phase defect.
Authors and Affiliations
Col Jasvinder Kaur Bhatia, Col Jagdeep Singh Bhatia
Keywords
Related Articles
- EP ID EP479607
- DOI -
- Views 86
- Downloads 0
Rewarming After Severe Accidental Hypothermia
Abstract: Although accidental hypothermia is considered a totally preventable cause of death, severe hypothermia (<28oC) carries a mortality rate about 21%. That’s why conventional rewarming techniques such as using a wa...
Peripheral Arterial Disease in Proven Coronary Artery Disease
Abstract: Peripheral arterial disease (PAD) is a predictor of cardiovascular morbidity and mortality leading to adverse outcome. It is a marker of increased risk of cardiovascular events in patients with coronary arteria...
Role of Sublingual Misoprostol to Reduce Blood Loss at Delivery by Cesarean
Abstract: This prospective randomized controlled study was carried with the purpose of assessing the efficacy of sublingual misoprostol in decreasing intra-operative blood loss and the need of additional uterotonic agent...
Frequency of Rh D, C, c, E, e and Kell1 Antigens among Sudanese Patients with Sickle Cell Disease: A prospective Study from Khartoum, Sudan
Sickle cell disease (SCD) is a group of haemoglobin disorders that increase the rate of morbidity and mortality. Blood transfusions have reduced morbidity and mortality for patients with SCD, but it can lead to erythrocy...
Relationship between Cardiovascular Parameter and General and Visceral Obesity Indices- A Review
Obesity is a growing problem particularly in countries of Asia-Pacific region where individuals may exhibit a relatively normal BMI (<25 kg/m2) but have a disproportionately large waist circumference. Asian Indians have...