Study of Corpus Luteum Function in Infertile Women by Timed Endometrial Biopsy and Progesterone Assay in the Diagnosis of Luteal Phase Defect
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 8
Abstract
Luteal phase defect is an improper development of endometrium for nidation, either due to decreased secretion of progesterone by the corpus luteum or when the effect of progesterone is limited at the endometrium. Both primary infertility and recurrent abortions have been found associated with this defect, however the diagnosis is difficult as there are no defined criteria for diagnosis. Aim of the study was to evaluate corpus luteum function in infertile women by timed endometrial biopsy and progesterone assay in the diagnosis of luteal phase defect. Cross sectional prospective study. Fifty infertile women with regular periods and a normal menstrual flow were included. The patients were evaluated by midluteal endometrial biopsy and serum progesterone. The tests were done on the same day in each patient, in the mid luteal phase. Delay of more than 2 days was taken as luteal phase defect. Age matched, fertile, normally menstruating women were taken as controls. Result: 44 patients were within two days of the chronological dating. 6 endometria were dated as more than two days short of the chronological date. Four cases showed coordinated delay and 2 cases showed dissociated delay. Six endometria showed proliferative phase endometrium. Mean progesterone level of 6.8+ 1.75 ng/ml was found in patients of luteal phase defect. Conclusion: Endometrial biopsy specimen provides an accurate measure of quantitative progesterone effect on corpus luteum function and also of the response of endometrium to the steroid stimuli and therefore is recommended for the diagnosis of luteal phase defect.
Authors and Affiliations
Col Jasvinder Kaur Bhatia, Col Jagdeep Singh Bhatia
Keywords
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