Study of correlation of serum protein levels with tuberculosis
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2016, Vol 20, Issue 2
Abstract
Background: It is well established that changes in levels of serum proteins occur in response to both acute and chronic infections. This is especially true of immunoglobulins and acute phase proteins. Serum protein levels change in an infection like tuberculosis, however, its role in diagnosis and prognosis is not clear. In the present study an effort has been made to explore the correlation of serum proteins levels with the severity of tuberculosis. Material and Methods: The study subjects included 100 patients above 12 years of age without HIV co-infection of newly diagnosed cases of pulmonary and extrapulmonary tuberculosis diagnosed. Serum total protein was measured by biuret method, whereas serum albumin was measured by dye-binding technique and the globulin fraction was determined by subtracting the albumin from the total protein. Results: Out of the 100 cases of tuberculosis collected from our hospital, 55 patients were PTB, and 45 were of extra-pulmonary tuberculosis. Total protein levels were found to be decreased in 23% of cases. While it was normal in mild cases, 20% of patients with moderate lung involvement and 44% with severe involvement had decreased protein level. Hypoalbuminaemia was found more frequently, the levels decreasing as the severity of the disease increased. Thus the decrease in total protein and albumin levels was proportionate to the extent of the disease. Discussion: Significant changes in the levels of several serum proteins have been observed to be associated with tuberculosis. Though they may not be of diagnostic value, they do, however, indicate the response of the body to the infection and recovery after treatment.
Authors and Affiliations
Laxmikant Chavan, Saket Kumar Mandal, Raju M Jotkar
Keywords
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