Study of correlation of serum protein levels with tuberculosis
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2016, Vol 20, Issue 2
Abstract
Background: It is well established that changes in levels of serum proteins occur in response to both acute and chronic infections. This is especially true of immunoglobulins and acute phase proteins. Serum protein levels change in an infection like tuberculosis, however, its role in diagnosis and prognosis is not clear. In the present study an effort has been made to explore the correlation of serum proteins levels with the severity of tuberculosis. Material and Methods: The study subjects included 100 patients above 12 years of age without HIV co-infection of newly diagnosed cases of pulmonary and extrapulmonary tuberculosis diagnosed. Serum total protein was measured by biuret method, whereas serum albumin was measured by dye-binding technique and the globulin fraction was determined by subtracting the albumin from the total protein. Results: Out of the 100 cases of tuberculosis collected from our hospital, 55 patients were PTB, and 45 were of extra-pulmonary tuberculosis. Total protein levels were found to be decreased in 23% of cases. While it was normal in mild cases, 20% of patients with moderate lung involvement and 44% with severe involvement had decreased protein level. Hypoalbuminaemia was found more frequently, the levels decreasing as the severity of the disease increased. Thus the decrease in total protein and albumin levels was proportionate to the extent of the disease. Discussion: Significant changes in the levels of several serum proteins have been observed to be associated with tuberculosis. Though they may not be of diagnostic value, they do, however, indicate the response of the body to the infection and recovery after treatment.
Authors and Affiliations
Laxmikant Chavan, Saket Kumar Mandal, Raju M Jotkar
Keywords
Related Articles
- EP ID EP498662
- DOI -
- Views 111
- Downloads 0
Study of serum uric acid and erythrocytic superoxide dismutase levels in gestational diabetes mellitus and normal pregnancy
Level of non-enzymatic antioxidant like serum uric acid and enzymatic antioxidant like superoxide dismutase is found to be deranged in patients of gestational diabetes mellitus. Serum uric acid and superoxide dismutase l...
A study of clinical profile and factors associated with uveitis at tertiary health care center
Introduction: Uveitis is a relatively common eye disease and one of the most important causes for visual impairment throughout the world. Aims and Objectives: To Study clinical profile and factors associated with Uveiti...
A study of anemia with respect to severity of tuberculosis
Background: Tuberculosis (TB) may produce abnormalities in the peripheral blood, including anemia. TB and anemia are both prevalent in India. There is limited and inconsistent literature on the association between anemia...
Bilateral peri-renal lymphangiectasia
Renal lymphangiectasia is a very rare benign disorder where there is dilatation of the perirenal and peripelvic lymphatics. The condition is commonly misdiagnosed as other cystic lesions of kidney. We present USG and CT...
Knowledge and Attitude of School Girls about Reproductive Health
Increased awareness about reproductive health amongst young girls is expected given the rate of growth of print and electronic media in India. Does availability of modern communication make us wise or we are just literat...