Study of Cryptosporidiosis in Children with Hematological and Solid Malignancies Suffering From Diarrhea
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 7
Abstract
Introduction: Cancer is the second leading cause of death in children under 15 years of age. Childhood cancers (CC) include a variety of malignant tumors. Leukemia is constituted about 30 − 34% of all CC. Central nervous system (CNS) cancers are the second most frequent cancers, accounting for about 27% of CC. Lymphomas represent the next most common type of CC, averaging 15%.Patients with cancer suffer from an increased risk for common and opportunistic infections that result from intrinsic disease and anticancer therapy-induced immune deficiencies. Opportunistic enteric protozoan parasites such as Cryptosporidium spp and Microsporidia may cause severe diarrhoea, morbidity and even mortality among immunocompromised patients. Cryptosporidiosis has been reported in both immunocompetent and immunocompromised patients and it has three major clinical presentations, including; asymptomatic carriage, acute diarrhea, and persistent diarrhea. Subjects: The study will be conducted on children aged 6 months - 16 years. It will include the following: 166 subjects, 83 immunocompromised children with diarrhea presenting to Alexandria University Children’s Hospital at Elshatby and 83 age matched control cases. Methods: Collection of Stool samples, Stool examination by Modified Ziehl - Neelsen stain for the diagnosis of C. parvum and Copro-antigen detection test using Rida Screen cryptosporidium ELISA kit. Results: Cryptosporidium infestation was significantly more frequent in studied patients suffering from malignancy as compared with control group. Conclusion: children with cancer are more likely to suffer from severe gastrointestinal manifestations due to the disease itself or infectious and non-infectious complications of chemotherapeutic treatment. Cryptosporidium infection should be considered in cases of severe or prolonged watery diarrhea in children with cancer which necessitates appropriate management to decrease its complications.
Authors and Affiliations
Magdy Abd Elfattah Ramadan
Keywords
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