Study of cytodiagnosis of thyroid neoplastic lesions and comparison with histopathology
Journal Title: International Journal of Medical Science and Public Health - Year 2016, Vol 5, Issue 1
Abstract
Background: One of the major advancement in anatomic pathology is found to be the improvements in aspiration cytology. Cancer is found to be one among the 10 leading causes of mortality in India. The advantages of FNAC are: safety, quick results, sensitivity and specificity for the diagnosis of malignancy, less requirement of equipments, minimal discomfort caused to the patient, an outpatient procedure, nonuse of frozen sections, reduction in the rate of exploratory procedures, definitive diagnosis of inoperable cases, repeatable, and cost-effective. Fine needle aspiration cytology (FNAC) is of particular significance in thyroid lesions, because of easy accessibility; outstanding patient adherence; being a minimally invasive procedure; and aid in avoiding the surgery in nonneoplastic lesions, inflammatory conditions, and some tumors. Objective: To test the utility of FNAC, establish the diagnostic accuracy of cytology by comparison with histopathology diagnosis, and establish the sensitivity and specificity of this technique in thyroid neoplastic lesion. Materials and Methods: This study was undertaken in the Department of Pathology, Government Medical College and Hospital, Nashik, between January 2008 and June 2009. All cases were studied with initial clinical evaluation, followed by FNAC, and subsequent histopathology wherever needed. Result: Of the total 84 cases of neoplastic thyroid lesions, 22 (26.19%) cases were malignant and 62 (73.81%) cases benign. Of the total 84 cases, 16 (19.05%) cases were male and 68 (80.95%) cases female subjects. The most common age group affected was found to be 51–60 years (23.81%). Of the total 84 aspirates, 20 (23.81%) cases were available for follow-up and histopathology examination. Of these 20 follow-up cases, cytological diagnosis and histopathological diagnosis were the same in 16 (80%) cases, whereas they were different in 4 (20%) cases. Conclusion: Excisional biopsy remains the gold standard for the diagnosis of thyroid neoplastic lesion; cytological study can establish the diagnosis of the majority of thyroid neoplasm and can be recommended as an adjunct to histopathology.
Authors and Affiliations
Navin R Patel, Asha P Gunjalia, Harshid L Patel
Keywords
Related Articles
- EP ID EP95814
- DOI 10.5455/ijmsph.2016.0206201511
- Views 136
- Downloads 0
A cross-sectional study on dementia in elderly persons living in old-age homes of Hyderabad, Telangana
Background: Dementia (cognitive impairment) is characterized by gradually declining memory and other cognitive abilities which reduce the quality of life of elderly people. The World Health Organization estimated that 2/...
Healthy aging conceptualizations in Saudi Arabia: a systematic review
The concepts of healthy aging have been growing in recent years. Based on searches of literature on aging, there are limited studies that address healthy aging issues for older population in Saudi Arabia. A system...
A study of adherence pattern toward antihypertensive therapy (antihypertensive drugs, dietary habits, and physical activity) and certain factors affecting it
Background: Adherence to antihypertensive treatment (pharmacological intervention and lifestyle modification)and related factors is an essential to hypertension (HTN)management and aids in planning intervention for its c...
Integrated yoga therapy for mastalgia
Mastalgia has neither an organic etiology nor any definitive treatment, which affects women’s quality of life during their reproductive lives. Considering mastalgia as one of the psychosomatic disorder, mind–body inter...
Bilateral fibroadenoma of the ectopic breast tissue in axilla: A case report
Anomalies associated with breast development are common, presenting as supernumerary nipples (polythelia) and less often as supernumerary breast (polymastia) in 1 – 5% of population. These anomalies are more common in...