Study of Dermal Vascular Changes in Inflammatory Skin Diseases
Journal Title: Saudi Journal of Pathology and Microbiology - Year 2018, Vol 3, Issue 3
Abstract
Abstract:The skin is the largest organ in the body. A multitude of diseases are linked to an insufficient or overactive dermal vasculature. Vessels change their phenotype,i.e. vascular remodelling in inflammatory conditions. The aim of this study was to analyse the dermal vascular alterations in various inflammatory skin diseases & to assess their utility in establishing the differential diagnosis. A unicenter study of 55 (fifty five) skin biopsies received from patients of various non tumorous common inflammatory skin diseases such as, psoriasis, lichen planus, erythema multiform, blistering (bullous) lesions and 10 control samples were studied. Morphometric analysis was performed on CD 34 immunostained sections using image analysis software (Leica Q Win V3 software analysis system). Mean vascular density (MVD) and mean vascular calibre (MVC) was calculated. The MVD was maximum in psoriasis, followed by lichen planus, bullous lesions and erythema multiform. MVD in psoriasis was significantly higher than the controls. MVC was highest in psoriasis followed by erythema multiform, lichen planus and bullous lesions. The MVC in psoriasis, erythema multiform, lichen planus, bullous lesions were significantly higher than the controls. Elongated, tortuous blood vessels were more prominent in psoriasis. The endothelial changes noted were swelling in the form of nuclear hypertrophy, increased cytoplasm and endothelial gaps. Angiogenesis was increased in inflammatory skin diseases and it was highest in psoriasis. Therefore, therapeutic intervention at the level of vasoproliferation may prove to be useful. Keywords: Psoriasis, Lichen Planus, bullous lesions, Mean vascular density, Mean vascular calibre.
Authors and Affiliations
Charusheela R Gore, Pradnya Shende, Sourabh P Paranjape, Padmakar R Bardapurkar, Shirish S Chandanwale, Namrata Patro
Keywords
Related Articles
- EP ID EP399431
- DOI -
- Views 62
- Downloads 0
Salivary Duct Cyst of Parotid Gland– A Case Report
Abstract: Swellings of the major salivary gland commonly lead to the differential diagnosis which includes benign and malignant tumors that are frequently associated with cystic degeneration or entirely cystic de novo. O...
Ecotoxicity Strength of Granular Domestic Detergents on Enterobacteraerogenes and Pseudomonas fluorescens
Ecotoxicity strength of different granular domestic detergents on Enterobacter aerogenes and Pseudomonas fluorescens was evaluated to assess the response of the test organisms to different brands of domestic detergents....
Histologic Patterns of Benign Breast Diseases in a Niger Delta Population: A Five Year Review
Abstract: Lumps in the breast are common especially in women of reproductive age, majority of these lumps which mimic or are suspected to be breast cancers clinically and radiologically are later found to be benign...
Spectrum of Histological Lesions in the Prostatic Specimens – A Two Year Study
Abstract:Prostate gland of male reproductive system is about the size of walnut and surrounds the urethra. With increasing life expectancy, increasing awareness and better health services, lesions of prostate has become...
Evaluation of Antibacterial Activity of Achyranthesaspera Extract against Vibrio alginolyticus: An in Vitro Study
Abstract:Marine organisms are potential sources of unique natural products with pharmacological and biological activities. In mariculture, diseases of microbial origin can cause huge economic losses worldwide. The evolut...