STUDY OF DIASTOLIC DYSFUNCTION IN YOUNG (< 40 YEARS) NEWLY DETECTED DIABETES AND ITS CORRELATION WITH OBESITY, GLYCAEMIC LEVELS AND DYSLIPIDAEMIA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 3
Abstract
BACKGROUND Left Ventricular Diastolic Dysfunction (LVDD) represents the first stage of diabetic cardiomyopathy preceding changes in systolic function, reinforcing the importance of early examination of ventricular function in individuals with diabetes mellitus (DM). This cross-sectional study was conducted to determine the incidence of asymptomatic LVDD in young (less than 40 years) and newly diagnosed normotensive cases of type 2 diabetes subjects, and its relation to glycosylated haemoglobin (HbA1c), body mass index (BMI) and serum total cholesterol. Aim and Objective- To study the incidence of left ventricular diastolic dysfunction (LVDD) and its correlation with HbA1c in young (< 40 years) normotensive, newly diagnosed type 2 diabetic patients. MATERIALS AND METHODS This cross-sectional study was done in rural Bangalore on 160 young (< 40 years) patients of newly diagnosed (within 1 month) type 2 DM visiting the Medicine outpatient, Rajarajeswari Medical College, Bangalore. Patients with established type 2 diabetes and already taking antidiabetic treatment, cardiac diseases like valvular heart disease, ischaemic and hypertensive heart disease, congestive heart failure, cardiomyopathy, renal failure, chronic pulmonary disease, severe anaemia and haemoglobinopathies were excluded from the study. These patients were informed about the study and informed consent was obtained before proceeding with the investigations. Patients selected were evaluated with relevant investigations like body mass index (BMI), fasting blood sugar, HbA1c level, total cholesterol and 2D echocardiography to assess LVDD. These selected patients were divided into 2 groups; one with left ventricular diastolic dysfunction (LVDD) and second group of subjects without LVDD. Various parameters like HbA1c, body mass index and serum total cholesterol were evaluated between these 2 groups. Statistical analysis was performed using SPSS software version 16. RESULTS Out of 160 patients, 114 were males and 46 were females. Baseline characteristics as in Table 1. Mean age of the population was 35.79 + 2.8 years, mean BMI were 26.15 + 2.7 kg/m2, mean HbA1c was 7.9 + 1.24 and mean serum total cholesterol were 250.43 + 37.3. Overall incidence of LVDD was 31.2%. Grade 1 LVDD was the most common. Mean level of HbA1c, BMI, serum total cholesterol and LVDD group was found statistically higher as compared to those without LVDD. CONCLUSION Nearly one-third of newly diagnosed type II diabetic patients were found to have diastolic dysfunction independent of confounding effect of hypertension and ischaemia. Most of the newly diagnosed diabetes with morbid obesity and high HbA1c level were found to have LV diastolic dysfunction irrespective of the age. HbA1c and BMI were found to be strong indicators of LVDD in young newly diagnosed cases of Type 2 DM, both in male and female sex. HbA1c emerges as an important indicator of diastolic dysfunction in early onset diabetes population in the study.
Authors and Affiliations
Ram Anil Raj M. R, Yogesh K Kothari, Kumar Kenchappa, Narayan Raju, Rajiv Girdhar
Keywords
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- EP ID EP284669
- DOI 10.14260/jemds/2018/76
- Views 58
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