Study of dimorphic anemia in adults with reference to basic etiology
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 1
Abstract
Objective To investigate the basic cause of dimorphic anemia in adult patients using hematological parameters bone marrow iron stores serum vitamin B12 and folate assaysMaterials and Methods Hematological parameters and bone marrow serum vitamin B12 and folate assays of 62 patients with dimorphic anemia were studied to evaluate the basic etiology in dimorphic anemiaResults The mean MCV was 95011314fl and MCV was normal in 5645 cases BM examination showed megaloblastic maturation in 3236 megaloblastic with micronormoblastic maturation in 6452 cases BM iron stores were deficient in 3226 cases 4355 cases had only folic acid deficiency 1935 cases had only B12 deficiency and 2742 cases had both B12 and folate deficiency Combined iron and vitamin deficiencies in 258 cases The mean MCV MCH MCHC and RDW were significantly high in combined deficienciesConclusion The common basic cause for dimorphic anemia was folate deficiency MCV is unreliable as a screening parameter for anemia with vitaminB12 or folate deficiencies Concomitant deficiencies of B12 or folate with iron deficiency are not infrequent one type of anemia may mask the other Serum assays will be appropriate to establish the cause in cases with concomitant deficiencies as it may result in discordant results with various other tests like hematological parametersKeywords Anemia Dimorphic Folate Megaloblastic Myelodysplasia Vitamin B12
Authors and Affiliations
Deepthi. A, CSBR Prasad, Raghavendra Prasad B. N.
Keywords
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- EP ID EP473185
- DOI 10.18231/2394-6792.2018.0012
- Views 61
- Downloads 0
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