STUDY OF DUAL IN VITRO ACTIVITY OF COLISTIN & MEROPENEM AGAINST MULTIDRUG RESISTANT GNB
Journal Title: PARIPEX-Indian Journal of Research - Year 2018, Vol 7, Issue 4
Abstract
Background: Bacterial resistance towards antibiotics is a clinical threat because it increases the problem of infectious disease. Currently colistin is increasingly being used against multidrug resistant gram negative bacteria which include Pseudomonas aeruginosa,,Acinetobacter baumanii, Escherichia coli, Klebsiella pneumoniae & Salmonella enterica. [1]. Combination antibiotic therapy is frequently used to treat severe gram negative infections though controversial & debatable. Methods: Total 200 MDR GNB isolates were included in the study which were further tested for their susceptibility to Colistin & Meropenem by Kirby Bauer Disc Diffusion Test. Results: Of 200 MDR GNB isolates, 69(34.5%) isolates showed resistance to Colistin.Out of 69 Colistin resistant isolates, 55(79.71 %) were resistant to Meropenem as well. Conclusion: As multidrug resistance is emerging rapidly,measures are necessary to restrict indiscriminate use of antimicrobials against common infections & adherence to the hospital antibiotic policy, which will further limit dissemination of bacteria that accumulate resistance to both colistin & carbapenems &/or to multiple antibiotics.
Authors and Affiliations
Dr. Sandhya S. Kulkarni, Dr. Ketaki Vyankatesh Kulkarni
Keywords
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