STUDY OF DYNAMICS OF CHANGES IN THE LEVEL OF SOME BLOOD CITOKINS IN PATIENTS WITH VARIOUS TYPES OF COMPLICATED PANCREATIC PSEUDOСYST
Journal Title: Science Review - Year 2018, Vol 4, Issue 3
Abstract
The study of TGF-β1, IL-6, IL-10, IL-18, IL-8 in patients with complicated pseudocysts has been performed. The obtained data, testify to one of the leading roles of TGF-β1 in the development of intra-and perilobular fibrosis, regardless of the trigger mechanism of pancreatitis and its complications. It has been established that the definition of circulating TGF-β1 may reflect the different stages of pancreatitis and the severity of the complications that develop at different times from the moment of the disease. Il-10, a powerful TGF-b1, controls the regeneration phase, reduces fibrosis and atrophy, and IL-18 stimulates apoptosis. Thus, the data obtained by us confirm the hypothesis that the activation of pro-inflammatory cytokine IL-18 and anti-inflammatory cytokine IL-10 can form a link between the risk factors for the development of complications in patients with different types of pancreatic pseudocyst.
Authors and Affiliations
I. A. Kryvoruchko, N. Нoncharova, S. M. Teslenko, A. V. Syvozhelizov, A. G. Drozdova, P. V. Svirepo, O. I. Prokhorov, I. M. Timofeev
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