Study of Effect of Dexmedetomidineand Clonidine as Adjuvant with Bupivacaine on the onset & Duration of Analgesia and Anaesthesiain Supraclavicular Brachial Plexus Block
Journal Title: Scholars Academic Journal of Pharmacy - Year 2017, Vol 6, Issue 6
Abstract
Many adjuvants have been used with local anaesthetics to reduce the time of onset and prolong the duration of analgesia in brachial plexus blocks.Very few studies are there comparing dexmedetomidine versus clonidine as adjuvant. This study was done to compare the effects of dexmedetomidine and clonidineas adjuvant to local anaesthetics in supraclavicular block.In this double blinded clinical trial, 90 ASA classes I and II patients posted to undergo upper extremity surgery were divided into 3 different groups randomly. Group C patients received 35 ml of 0.25% bupivacaine and Clonidine (1 mcg/kg), Group D patients received 35 ml of 0.25% bupivacaine and Dexmedetomidine (1 mcg/kg), while group B received 35 ml of 0.25% bupivacaine only in supraclavicular brachial plexus block. Time of request for 1strescue analgesia, onset and duration of sensory motor blocks and changes in hemodynamic parameters were studied and analyzed. Time for request for rescue analgesia was delayed in group D compared to groupB and C.The mean of sensory and motor block onset time in group D was less than in group B and C, the difference between the two group being statistically significant(p<0.001).In group D mean duration of sensory block was prolonged compared to group B and C, which was statistically significant(p<0.001). The addition of dexmedetomidine as adjuvant to bupivacaine in brachial plexus blockade delayed the requirement of rescue analgesia with decreased onset time and prolonged duration of sensory and motor block characteristics compared to clonidine. Keywords:supraclavicular block, dexmedetomidine, bupivacaine.
Authors and Affiliations
Dr. Harekrishna Ray, Kamala Kanta Pradhan, Dr Soumyakant Sethi, Dr. AmulyaRanjan Dash
Keywords
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