Study of Effect of Dyslipidemia And Insulin Resistance on Colorectalcancerriskpatients in A Teaching Hospital of India
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Background & Objective: India, according to Indian Council of Medical Research (ICMR,) the annual incidence rates (AARs) for colon cancer and rectal cancer in men are 4.4 and 4.1 per 100000, respectively. The AAR for colon cancer in women is 3.9 per 100000. Some studies have shown that the incidence of CRC is associated with obesity, hyperinsulinemia, and diabetesmellitus. However, studies on the association between CRC anddyslipidemia and insulin resistance produced conflicting results. Patients and Methods: The case-control study was conducted including total 190 subjects. A total of 95 colorectal cancer patients in which 54 (56.8%) males and 41(43.1%) females newly diagnosed with histologically confirmed colorectal carcinoma, under the age of 80 (range 40-80 years). Controls were 95 age matched disease free individuals in which 52 (54.7%) males and 43 (45.2%) females. Mean ± SD in case and control groups and compared using the Unpaired Student’s t-test. Results: Data revealed that BMI, total cholesterol, LDL-C, triglycerides, VLDL-C, fasting glucose, serum insulin, HOMA-IR and CEA were significantly differing in between both male and female cases and controls. HDL-C was significantly low (P < 0.001) in only male cases as compare to male control. Conclusion: The present study confirms the association between dyslipidemia, insulin resistance and the prevalence of colorectal cancer.
Authors and Affiliations
Purnima Dey Sarkar, Poonam Kachhawa, Kamal Kachhawa, Madhavi Dubey, Vivek Sinha
Keywords
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- EP ID EP251448
- DOI 10.9790/0853-1612090813
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