Study of Effect of two dosage regimens of Vitamin D in Obese, Vitamin-D insufficient adults

Apply

Study of Effect of two dosage regimens of Vitamin D in Obese, Vitamin-D insufficient adults

Journal Title: The Indian Practitioner - Year 2015, Vol 68, Issue 12

Abstract

Vitamin D deficiency is found to be common in variety of conditions like diabetes mellitus and obesity. There is scarce data regarding the dose and duration of Vitamin D treatment in such patients. Adults were screened for presence of Vitamin D insufficiency by chemiluminescent immunoassays and studied for the effect of 2 dose regimens for 2 months. After confirming Vitamin D insufficiency (< 30 ng/mL), they were treated with either 3 lakh IU (I.M.)/month or 6 lakh IU (I.M.)/month (n=13 each). Vitamin D was estimated monthly. Results of our study show that Vitamin D deficiency is common in obese patients. At the end of one month, administration of Vitamin D resulted in significant (p < 0.05) improvement in Vitamin D levels in both these groups. Vitamin D levels in these two groups were comparable at the end of 1 month (25.28 ± 3.75ng/mL and 26.16 ± 3.72ng/mL). However further administration of Vitamin D significantly (p < 0.05) improved the levels of Vitamin D in patients receiving the higher dose 6 lakh IU (33.28 ± 2.55 ng/mL) vs. 3 lakh IU (31.52 ± 3.29). There was no evidence of Vitamin D toxicity. Hence, administration of Vitamin D in the dose of 6 lakh units (I.M.)/month might be a better regimen than 3 lakh IU (I.M.)/month to correct Vitamin D deficiency in these patients. However, the exact duration of treatment was necessary to maintain the Vitamin D level in normal range, needs to be determined by further studies.

Authors and Affiliations

S V Dange, S H Patil

Keywords

Evaluation of Function after Proximal Femoral Varus Osteotomy for Perthes Disease (avascular necrosis of the proximal femoral head)

Background: Among the various methods of containment, femoral osteotomy is being widely used. The results are yet to be completely understood. Material and Method: 20 Cases of Perthes disease underwent femoral osteotomy...

Bacteriological Profile and antimicrobial Susceptibility Pattern among patients with chronic Suppurative Otitis Media Hospital based study in India

The objective of the study was to identify the microflora and their antimicrobial sensitivity pattern in chronic suppurative otitis media (CSOM). The study was conducted on patients in Rohilkhand region. Eighty patients...

EP ID EP587734
DOI -
Views 70
Downloads 0