Study of Efficacy and Safety of 5-Fluorouracil in Trabeculectomy
Journal Title: Ophthalmology and Allied Sciences - Year 2019, Vol 5, Issue 1
Abstract
Background: In majority of cases of glaucoma the disease progresses in such a slow symptomfree course, that by the time patient, seeks help from the ophthalmologist, a great deal of permanent damage has occurred already. Thus, delay on the part of patient in many cases is due to his ignorance about glaucoma. The present study was undertaken to assess the efficacy & safety of intraoperative 5 – Fluorouracil in Trabeculectomy. Methods: The present study was undertaken in the Department of Ophthalmology, ARMCH & RC, Kumbhari and cases which were diagnosed clinically as having primary glaucoma with raised intraocular tension were randomly selected to receive or not to receive intraoperative 5 – Fluorouracil application between conjunctival flap and sclera for 1 minute duration. Results: There was 67% reduction in baseline intraocular tension with intraoperative use of 5 – Fluorouracil while 58% reduction in baseline intraocular tension was observed without use of 5 – Fluorouracil. Intraocular tension was controlled below 15 mmHg in 92% cases with intraoperative use of 5 – Fluorouracil and 64% cases without use of 5 – Fluorouracil. In high risk glaucoma, adequate control of intraocular tension was observed with intraoperative use of 5 – Fluorouracil. Conclusion: It is a safe and effective alternative to subconjunctival injections of 5 – Fluorouracil. It is also useful in controlling the intraocular tension in high risk eyes.
Authors and Affiliations
Manjunath D Patil
Keywords
Related Articles
- EP ID EP648679
- DOI 10.21088/oas.2454.7816.5119.9
- Views 74
- Downloads 0
Corneal Ulcer: A Case Series Study
Aims and Objectives: To identify the specific pathogenic organisms risk factors responsible for infection in corneal ulcer patient. Materials and Method: The present study was undertaken on 200 patients of corneal ulcer...
A Study in Dry Eye Among Patients with Pterygium at A Tertiary Care Centre, Narayana Medical College, Nellore
Aim: To find out the proportion of Dry eye among patients affected with Pterygium. Materials And Methods: It was a cross-sectional study. The patients with clinical diagnosis of Pterygium were selected. Ocular examinatio...
Retinopathy of Prematurity (ROP): A Curse for Low Birth Weight Neonates
Introduction: Advances in neonatology and ventilator systems, results in exposure of preterm and low birth weight babies to high oxygen concentration there by leading to initiating ROP. This study was done to identify th...
Prevalence and Risk Factors in Primary Open Angle Glaucoma of Patients Attending Ophthalmology OPD at Kims, Hubballi
Context: Glaucoma is the largest cause of bilateral blindness, second only to the cataract; however, the disability caused by glaucoma is irreversible. According to the World Health Organization model, based on the most...
The Prevalence of Glaucoma: Study From the Rural Area of Chhattisgarh, India
Aim: The main objective of the current study is toinvestigate that the prevalence and type of glaucoma inthe rural area of Chhattisgarh. Material and methods: A retrospective study was conducted inthe department of ophth...