Study of expression of P53 in Gastric Carcinoma – As a prognostic indicator
Journal Title: International Archives of Integrated Medicine - Year 2016, Vol 3, Issue 11
Abstract
Cancer of stomach remains the major cause of mortality worldwide despite a marked decline in the incidence of gastric carcinoma in the industrialized nations. Gastric cancer is the end result of multifactorial, multigenetic, multistep process. The knowledge of the factors that influence gastric carcinogenesis is determinant for the development of strategies effective for prevention and treatment. Our study emphasizes upon the role of p53 as a prognostic indicator of gastric carcinoma. 50 cases of gastric biopsies were taken at random over a period of 4 years, and p53 expression of these lesions was studied. Gastric carcinoma cases were followed and the TNM staging was assessed. In our study, p53 expression was associated with younger age group, increased depth of invasion and lymph node metastasis, thereby indicating that p53 is a prognostic indicator for gastric carcinoma.
Authors and Affiliations
K. Padma Malini, Dr. Srivani, O. Shravan Kumar
MRI is the modality of choice for evaluation of spinal lesions
Introduction: Spine is a longitudinal structure, and precise location of the level of a lesion from clinical examination can be difficult. MRI of spine shows the anatomy of the vertebrae that makes up the spine, as well...
Clinical study of efficacy of amniotic membrane grafting in the management of pterygium
Background: Pterygium is a triangular fibrovascular, subepithelial in growth of degenerative bulbar conjunctival tissue encroaching over the limbus onto the cornea located commonly horizontally in inter palpebral fissure...
Neonatal hiatal hernia on CPAP: A rare entity
Herniation of the stomach through the esophageal hiatus can occur as a common Sliding hernia (Type 1) in which the gastro esophageal junction slides into the thorax, or Paraesophageal (Type 2) in which a portion of the s...
A study on risk factors and clinical presentation of ectopic pregnancy in women attending a tertiary care centre
Aim: The present study was designed to study the ectopic pregnancy risk factors and their clinical presentation in ectopic pregnancy attending to a tertiary care center. Material and methods: It was a prospective study w...
Efficacy of Gabapentin on combined spinal epidural anesthesia for lower limb orthopedic surgeries
Background: Orthopedic patients can be particularly challenging for anesthesiologists. Many orthopedic procedures are well suited for regional anesthetic techniques. Epidural analgesia is the one method which can be perf...