Study of Frequency of Various Clinical Forms of Neonatal Cholestasis in Jharkhand: A Hospital Based Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Backkground: Neonatal Cholestasis occurs due to so many causes like- genetic, metabolic, obstructive & less commonly infective. It is never physiological. Aims & Objectives: To describe a stepwise approach for the evaluation of neonatal cholestasis, to understand the importance of early screening for neonatal cholestasis and to understand the frequency of various clinical forms of neonatal cholestasis. Methodology: It is a prospective cohort study, it will include 30 babies diagnosed as having Neonatal Cholestasis at Rajendra Institute of Medical Sciences, Ranchi, Jharkhand from 13 April 2018 to 31 January 2019. In this study descriptive and inferential statistical analysis of data will be done using suitable stastical method. Results: Of the 30 infants investigated, 12 diagnosed as Biliary atresia(40%), 4 with Progressive familial intrahepatic cholestasis(13%), 3 with Premature delivery(10%), 3 with Infectious diseases(10%), 2 with Metabolic & Endocrine disorders(7%), 1 with Alagille syndrome(3%) & 5 cases are Idiopathic neonatal hepatits(17%). Conclusion: Biliary atresia is the most common entity leading to Neonatal cholestasis,It must be differentiated from other causes of cholestasis (PFIC , Infectious diseases,premature delivery, Metabolic & Endocrine disorders and Idiopathic neonatal hepatits) promptly because early surgical intervention before 2 months of age results in a better patient outcome.
Authors and Affiliations
Dr. U. P. Sahu, Dr. (Prof. ) A. K. Chaudhary, Dr. Gora Chand
Keywords
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- DOI 10.9790/0853-1803127883.
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