STUDY OF GLYCAEMIC BIOMARKERS IN THE PATIENTS OF THYROID DISORDERS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 72
Abstract
BACKGROUND Thyroid disorders are commonest disorders worldwide. Various glycated proteins can be used as glycaemic biomarkers to determine the degree of glycaemia in thyroid patients. They are useful glycaemic biomarkers to monitor the short-term glycaemic changes in the patients with thyroid disorders and have a role in conjugation with glycated haemoglobin. Serum fructosamine and glycated albumin correlate well with serum glucose. So, the present study was conducted to evaluate the changes and compare the levels of various glycaemic biomarkers like serum fructosamine, glycated albumin, glycated haemoglobin in overt hypothyroid, subclinical hypothyroid, hyperthyroid patients in comparison to controls and the levels of total protein and serum albumin was estimated in thyroid disorder patients. MATERIALS AND METHODS The present descriptive comparative study has been conducted on 300 subjects of either sex of various age groups. Study included diagnosed thyroid disorder patients (200) attending medical OPD, patients admitted in medical and surgical wards and patients coming in Radioimmunoassay (RIA) laboratory, Biochemistry Department, JLN Medical College and Hospital, Ajmer. The results of patients were compared with the hundred healthy subjects of either sex of similar age group. The indices included: - Serum fructosamine assayed by Nitroblue Tetrazolium Kinetic Method, Serum Glycated Albumin by Enzyme-Linked Immunosorbent Assay, Total protein by Biuret method, Fasting blood glucose by GOD-POD method and HbA1c by Ion-Exchange Resin Method. RESULTS The mean serum fructosamine were higher in overt hypothyroid and subclinical hypothyroid patients in comparison to healthy control, vice-a-versa was found in hyperthyroid patients (p < 0.001) (HS). Mean glycated albumin levels were higher in overt hypothyroid patients (p < 0.005) and subclinical hypothyroid patients in comparison to healthy control, vice-a-versa was found in hyperthyroid patients. Total protein levels were higher in overt hypothyroid and subclinical hypothyroid patients. Serum albumin levels were higher in overt hypothyroid patients in comparison to hyperthyroid and healthy control, which was statistically significant. CONCLUSION The present study concluded that serum fructosamine and serum glycated albumin are better short-term glycaemic markers than glycated haemoglobin and fasting blood glucose level in thyroid disorder patients.
Authors and Affiliations
Varsha Chowdhry, Kaushik G. G
Keywords
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- EP ID EP265602
- DOI 10.14260/Jemds/2017/1120
- Views 88
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