Study of hematological profile in sickle cell patient.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Background: Sickle cell disease is one of the most common autosomal recessive diseases in the world caused by a single nucleotide substitution (GTG - GAG) and is located at the sixth codon of the human-globin gene. Aims & Objectives: This study was designed to study hematological profile in sickle cell patient and compare hematological profile in sickle cell traits with sickle cell disease patient Materials and Methods: This study is an observational study done in 70 sickle cell patients in steady state, at Acharya VinobaBhave Rural Hospital, Sawangi Meghe, Wardha, MaharashtraIndia. The complete blood counts (CBC) were analyzed using the Automated Coulter Counter & Sickling pattern were identified on Hbelectrophoresis, at a pH of 8.6oncellulose acetatepaper. Results: Haemoglobin concentration and the MCV was significantly low (≤0.05) in sickle cell diseased patients as compared to sickle cell traits. TLC count was not significantly higher while platelets & red cell distribution width (RDW) were significantly higher (≤0.05) in sickle cell disease (SCD) patients, as compared to traits. Conclusion: Our study has explained haematological parameters & their role in sickle cell trait and sickle cell diseased which could be used in designing of the better management of sickle cell patients.
Authors and Affiliations
Suchita D Modi, Vikas R Agrawal, Arvind S Bhake, Anil Agrawal
Keywords
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- EP ID EP362403
- DOI 10.9790/0853-1702068285
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