Study of Hepatotoxicity Induced By Anti-Tuberculosis Drugs in Patients Co -Infected With HIV and Tuberculosis at Coimbatore Medical College and Hospital.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 5
Abstract
Human Immunodefieciency Virus (HIV) infection / Acquired Immuno Deficiency Syndrome (AIDS) is a global pandemic which has significant impact on the epidemiology of Tuberculosis. Progression of Mycobacterium Tuberculosis infection to active tuberculosis is more rapid and common in those infected with HIV than without HIV infection, so HIV/AIDS is an independent risk factor for TB disease progression(1). Aim: The purpose the study is to estimate the incidence of hepatotoxicity in peoples withco-infection of HIV and Tuberculosis and to determine the associated risk factors like alcohol consumption, age, gender, HBsAg, Anti HCV and CD4 count.Method of the study: 100 peoples with HIV and co infected with TB were studied in a tertiary care hospital in Coimbatore. Result: A substantial number of cases (14%), with majority of hepatotoxic events occurred in the intensive phase of treatment, alcohol intake, extra pulmonary tuberculosis, low CD4 count,Hepatitis B/C co-infection were identified as risk factors to the development of ATT induced hepatotoxicity withlow CD4 count, alcohol intake, and Hepatitis B/C virus infection passing as independent predictors.The findings suggest that HIV-TB coinfected patients presenting with alcohol intake, low CD4 count and Hepatitis B/C co-infection should be closely monitored by physicians especially during the intensive phase of Anti-Tuberculosis therapy for better patient management and for the prevention of morbidity and mortality.
Authors and Affiliations
Dr. N. Karuppusamy M. D, Dr. Sakthi, Dr. R. Nandhini Devi, Dr. C. Vignesh
Keywords
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- EP ID EP374481
- DOI 10.9790/0853-1705050511.
- Views 52
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