STUDY OF HYPOMAGNESAEMIA IN CRITICALLY-ILL PATIENTS IN MEDICAL INTENSIVE CARE UNIT AT TERTIARY CARE HOSPITAL
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 67
Abstract
BACKGROUND Magnesium is the second most abundant intracellular cation and the fourth most common cation in the body. The effect of magnesium on important biological processes such as glycolysis, oxidative phosphorylation, nucleotide metabolism, protein biosynthesis signifies the importance of magnesium in cellular metabolism. Magnesium plays a role in numerous enzymatic processes in the body and has direct role in activation of enzymes such as phosphofructokinase, creatine kinase, acetylate cyclase and sodium potassium ATPase. The aim of the study is to1. Study serum magnesium level in critically-ill patient. 2. Correlate serum magnesium level with patient outcomes. 3. Identify primary medical conditions and the factors predisposing or contributing to abnormalities of serum magnesium. MATERIALS AND METHODS Study of 100 cases admitted over a period of 2 years, i.e. between 2010 to 2012 in MICU at SSG Hospital, Vadodara. The patient admitted for critical illness in ICU was included in study. The patients who received magnesium before admission to MICU were excluded from study. A blood sample was collected for estimation of serum total magnesium level on admission to MICU. History and clinical finding were noted for each patient, other haematological, biochemical and radiological investigations were performed as indicated in every patient. RESULTS 66% were male and 34% were female patients. Hypomagnesaemia was found in 52%, normal level in 41% and hypomagnesaemia in 7%. Present study shows mortality and sepsis were statistically significant findings in study population, i.e. in patients with hypomagnesaemia (p<0.05). Statistically significant correlation was found with hypocalcaemia and hypoalbuminaemia in study populations (p<0.05). However, hypomagnesaemia doesn’t show significant association with duration of MICU stay, need of ventilator. CONCLUSION Hypomagnesaemia is a one of electrolyte imbalance in the critically-ill patients. Hypomagnesaemia is associated with higher mortality rate in critically-ill patients as Mg plays important role in homeostasis. Morbidity and mortality in critically-ill patient has relation with low Mg level. However, potential benefits of Mg supplementation to prevent or correct hypomagnesaemia in critically-ill patients require further study.
Authors and Affiliations
Sumit Kamble, Hetal Patel, Smita Trivedi
Keywords
Related Articles
- EP ID EP271999
- DOI 10.18410/jebmh/2017/805
- Views 98
- Downloads 0
EVALUATION ON THE SAFETY OF TICAGRELOR AMONG INDIAN ACUTE CORONARY SYNDROME (ACS) PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION
BACKGROUND Ticagrelor is the novel class of anti-platelet drugs, has a simpler and faster metabolism (rapid onset of action), high potency and most importantly reversibility. The latter makes this drug safer in patients...
ABDOMEN GROANS: A RARE CAUSE OF PANCREATITIS
Hyperparathyroidism and hypercalcaemia are considered to be a rare cause of acute pancreatitis. The relationship between hyperparathyroidism and pancreatic inflammatory disease remains controversial. (1) But it has been...
MANAGEMENT OF DISTAL FEMORAL FRACTURES- A COMPARITIVE STUDY BETWEEN SUPRACONDYLAR NAIL AND DISTAL FEMORAL LOCKING PLATE
BACKGROUND Distal Femoral Fracture (DFF) poses a considerable therapeutic challenge in management, despite new fixation options. Anatomic reduction, stabilisation, early weight bearing and mobilisation are the main aims...
A CROSS SECTIONAL STUDY OF RESPIRATORY CONDITION IN NON TEXTILE AND TEXTILE WORKERS
The purpose of this study was to determine the prevalence of respiratory symptoms among cotton-ginning workers. Byssinosis is a respiratory disease caused by inhalation of cotton dust for prolonged period of time. This i...
FREQUENCY AND DISTRIBUTION OF ABO & RH BLOOD GROUP IN BILASPUR DISTRICT OF CHHATTISGARH STATE: A STUDY FROM MEDICAL COLLEGE HOSPITAL
Approximate 30 blood group systems have discovered and more than 400 erythrocytes antigens are identified. Blood group ABO and Rh are most important among all other blood group systems in transfusion service practices. T...