Study of intravenously administered dexmedetomidine on isoflurane requirement and perioperative haemodynamic stability in elective surgery
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 9, Issue 3
Abstract
Background and Aims: In this study we observe the effect of dexmedetomidine as an adjuvant to general anesthesia on cardiovascular response to intubation and extubation, hemodynamic stability, requirement of Isoflurane concentration, postoperative recovery and sedation. Material and Methods: 60 patients were divided into 2 groups with 30 patients in each, undergoing elective surgical procedure. Group D patients received l µg/kg Dexmedetomidine i.v. over 10 min before induction, followed by 0.6µg/kg/hour infusion till end of surgery and Group S received normal saline intravenously at the same rate. A standardized anesthetic protocol was used. Monitoring of Hemodynamic parameters, Recovery Time, Sedation Score and end tidal concentration of Isoflurane were assessed. Statistical analysis was performed using 'p' value obtained from Student‘t’ test. Results: Hemodynamic response to intubation and Extubation, sedation score and recovery time were statistically different in both groups. End expiratory concentration of isoflurane required during anesthesia maintenance was 24.28% less in Group D in comparison to Group S(P<0.05). There was increase in heart rate and blood pressure in response to Extubation but in Group D patients this response in blunted by Dexmedetomidine. Conclusion: Dexmedetomidine maintains hemodynamic stability during surgery and reduce requirements of isoflurane without causing significant sedation.
Authors and Affiliations
Hemlata N Chaudhary, Bansari M Shah, Bharti R Rajani
Keywords
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- EP ID EP521143
- DOI 10.26611/1015932
- Views 165
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