STUDY OF IRON PROFILE IN SICKLE CELL PATIENTS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 42
Abstract
BACKGROUND Sickle cell disease is inherited as an autosomal recessive disorder that affects red blood cells. People with sickle cell disease contain abnormal haemoglobin, which is haemoglobin S. The aim of this study is to find out whether sickle cell patients are iron overloaded or iron deficient. MATERIALS AND METHODS This is a descriptive study. Concentrations of serum iron, total iron binding capacity and ferritin were analysed and compared between transfused and non-transfused sickle cell anaemia and sickle cell trait patients. RESULTS Serum iron was significantly more in sickle cell anaemia patients as compared with sickle cell trait patients. Serum ferritin was elevated more in patients who presented with features suggestive of vaso-occlusive crisis than those in steady state. Iron deficiency state was found more in sickle cell anaemia patients as compared to sickle cell trait patients, but iron overload state was also found only in those sickle cell patients who were hypertransfused. CONCLUSION Sickle cell disease, though a chronic haemolytic condition, can also present with iron deficiency and iron status of these patients varies according to their diet, number of transfusions received and number of crisis episodes. Therefore, we recommend that patients with sickle cell disease should be screened for iron deficiency by conventional laboratory tests.
Authors and Affiliations
Vrinda Sahasrabhojaney, Arun Solanki
Keywords
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- EP ID EP548493
- DOI 10.14260/jemds/2018/1007
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