Study of karyotypes in Case of Recurrent Abortions in Gujarat
Journal Title: BJKines-National Journal of Basic & Applied Science - Year 2015, Vol 7, Issue 1
Abstract
Introduction: - The biological definition of miscarriage is the expulsion of the conceptus before viability has been achieved. The definition of recurrent miscarriage is three or more consecutive spontaneous abortions. The risk factors for recurrent miscarriage are epidemiological, genetic, anatomical disorders, endocrinal, reproductive tract infections, thrombophilic disorders, disorders of materno-fetal alloimmune relationships, environmental effects and psychological causes. About 50% to 60% of all first trimester abortions are associated with derangement of one or more chromosomal complements. Aim: - The aim of this study was to assess frequency and increasing the awareness of physician about the nature of chromosomal aberration that contribute to the occurrence of repeated abortions. Material & Methods: - Patient of recurrent abortion was investigated by history taking, examination and investigations. For present study 20 women having two or more consecutive spontaneous abortions, who attended outdoor & indoor patient department, were selected and karyotyping was done. In 10 of the above cases karyotype study of both partners was done. So in total 30 individuals (20 females & 10 males) were selected for Cytogenetic study. In all cases relevant history and clinical findings and other investigations were noted. Blood samples were obtained and karyotype study was performed at Genetic Laboratory, B. J. Medical College, Ahmedabad. Results and Conclusions: - Cytogenetic evaluation by karyotypes revealed robertsonian translocation in one (5%) female; this patient had a history of 2 spontaneous abortions and two times IVF failure, she had history of chocolate cyst of ovary and family history of infertility. No numerical anomaly; mosaicism or inversions were found in this study; 23 cases had normal karyotype and remaining 6 cases came out inconclusive.
Authors and Affiliations
Niyati Parikh, Jitendra D. Rawal, SUNIL G. OZA, Brijesh Patel, Hrishikesh Jadav, Chandraprabha Pensi
Keywords
Related Articles
- EP ID EP514510
- DOI -
- Views 100
- Downloads 0
A study of physical growth parameters in patients of Thalassemia major.
Introduction: Thalassemia is the most common genetic disorder all over the world as per WHO and so pose a major public health burden in this millennium affecting the growth and the general well being of a large number of...
Clinical Study of Epidemiology and Histopathological Correlation of Lid Tumours in Indian Population.
Objective: To study the presentation, pattern of distribution and correlate histopathological examination of lid tumor. Materials and Methods: A prospective study of 50 patients presenting to tertiary referral care centr...
Perioperative Anaesthetic Management of Bladder Extrophy Patient
Reconstruction of bladder extrophy in infants and small children requires immobilization, sedation and pain management to prevent distracting forces from compromising the repair. We present 15 cases operated for bladder...
Comparative study between intrathecal nalbuphine and dexmedetomidine for post-operative analgesia in lower abdominal surgeries.
Background: Nalbuphine and Dexmedetomidine has been used intrathecally as an adjuvant in many studies. The purpose of our study was to establish the effectiveness of intrathecal nalbuphine as an adjuvant, and compare wit...
Indications and outcome of CO2 lasers in larynx in a Tertiary care center.
Background: Lasers are relatively newer and popular addition to the domain of laryngology. The lasers have offered a time and cost effective option to cold surgical techniques and have been used in the treatment of vario...