Abstract

Introduction: CRF affects multiple organs of human body like heart and brain. All these effects results due to dyslipidemia which is due to metabolic and endocrinal disturbances. Electrolyte level alterations are also observed in case of CRF patients. Materials and Method: This cross section study includes total 110 subjects. Out of these 60 subjects were clinically diagnosed CRF patients having age more than 20 years and remaining 50 subjects were chosen from healthy controls not having any major medical problem. Among 60 CRF cases, 30 were on maintenance dialysis for a period of 5 months to 3 years. These patients were undergoing dialysis for 3-4 hours thrice week, Other 30 patients were on conservative line of treatment. Fasting venous blood samples were collected and serum levels of Total cholesterol, Triglycerides, High density lipoprotein cholesterol, Low density lipoprotein cholesterol, Very low density lipoprotein cholesterol, Serum Na+& K+ were measured. Results: It is seen that Serum K+, total cholesterol, triglyceride, VLDL-C and total cholesterol to HDL-C ratio were significantly increased in CRF on conservative management group as compared controls while mean level of LDL-C did not show any significant difference between these two groups i.e. controls & CRF on conservative management. The mean value of Serum Na+ and HDL-C was significantly decreased in CRF on conservative management as compared to control. It is also observed that Serum K+, total cholesterol, triglyceride, VLDL C and total cholesterol to HDL ratio were significantly increased in CRF on dialysis group as compared controls while mean level of LDL did not show any significant difference between these two groups i.e. controls & CRF on dialysis. The mean value of Serum Na+, HDL-C was significantly decreased in CRF on dialysis group as compared controls. Conclusion: The present study indicates that due to dyslipidemia in CRF, there is increased risk of cardiovascular complications.

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