Study of Lipoprotein-associated Phospholipase A2 and Carotid Intima Media Thickness as Markers of Increase Cardiovascular Risk
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 5
Abstract
Introduction: Emerging risk markers that have demonstrated effectiveness in predicting risk for future cardiovascular disease events are carotid artery intima-media thickness (CIMT) and lipoprotein-associated phospholipase A2. The aim of our study was to compare Lp-PLA2 activity and CIMT in patients with risk factors of cardiovascular diseases. Material and Methods: This case-control study included adult subjects with risk factors of cardiovascular diseases as cases and healthy age and gender matched subjects as controls. LPPLA 2 activity was measured with ELISA method and CIMT measurements were made just before the bifurcation of common carotid artery by using B- mode ultrasound. Univariate and multivariate analysis was performed. A two-tailed P value <0.05 was considered statistically significant. Results: A total of 70 cases and 70 controls were enrolled in this study. Multivariable stepwise regression analysis revealed glycosylated hemoglobin, and non-HDL cholesterol as independent predictors of CIMT. Lp-PLA2 activity had no correlation with age, BMI, systolic blood pressure, diastolic blood pressure, lipid profile, serum uric acid, and CIMT. Conclusion: The results from the present study reveal that Lp-PLA2 activity increases with increment of number of cardiovascular risk factors. There was no relationship observed in predicting CIMT and Lp-PLA2 activity
Authors and Affiliations
Davendra Kumar, Ajay Kumar Mishra, Mehboob Subhani Siddiqui, Almas Qureshi
Keywords
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