Study of Mast cells in non neoplastic skin lesions – study on 72 cases
Journal Title: Perspectives In Medical Research - Year 2016, Vol 4, Issue 2
Abstract
Introduction: Skin, the largest external organ of human body, is associated with a gamut of lesions. Clinical manifestations include erythema, itching, edema, swelling, vesicles, bullae, alterations in pigmentation etc. Mast cell is an integral cellular component of skin and is believed to respond to diverse range of stimuli. Mast cells can regulate tissue changes that confer either a beneficial or a harmful effect depending upon specific circumstances. In the present study, an attempt is made to evaluate mast cell profile (density) in various non neoplastic skin lesions. No attempt is made to assess their role in different cutaneous disorders. Material and Methods:A prospective analytical histopathological study of non-neoplastic skin lesions was carried out during June 2004 –May 2005. A total of seventy two cases were included in this study. Results: Irrespective of category, lesions of bullous mastocytosis showed highest mast cell density and the lowest numbers were seen in scleroderma Conclusion: Majority of inflammatory lesions, infective and non-infective, showed definite changes in mast cell numbers and distribution patterns (like perivascular and interstitial) when compared to normal skin controls. Lesions with epidermal involvement showed increased number of mast cells in superficial dermis and lesions with dermal involvement showed dermal predominance of mast cells.
Authors and Affiliations
Prashanth Kumar M
Keywords
Related Articles
- EP ID EP306824
- DOI -
- Views 101
- Downloads 0
Conservative management of urethral prolapse in a five year old girl: A case report
Introduction:Urethral prolapse is a rare presentation. Among all the age groups it is commonly seen in prepubertal age. Most cases are asymptomatic, but if they present, the most common presentation is vaginal bleeding....
Study of Mast cells in non neoplastic skin lesions – study on 72 cases
Introduction: Skin, the largest external organ of human body, is associated with a gamut of lesions. Clinical manifestations include erythema, itching, edema, swelling, vesicles, bullae, alterations in pigmentation etc....
Impact of Endosulfan on Male Reproductive functions - a review
ntroduction: Endosulfan is an organochlorine insecticide and acaracide used to control a broad range of insect and arthropod pests on a wide variety of crops in many agrosystems. It can cause acute and chronic toxicity....
Pleomorphic adenoma of the minor salivary gland in parapharyngeal space - A rarity: Case report
Introduction: Pleomorphic adenoma (PA) can be defined as a benign mixed tumor composed of epithelial and myoepithelial cells arranged in various morphological patterns, demarcated from surrounding tissues by a fibrous ca...
Septicemia Induced ARDS Mimicking Transfusion Related Acute Lung Injury
Introduction: Severe Sepsis may cause acute lung injury mimicking Transfusion Related Acute Lung Injury (TRALI)and may pose a diagnostic challenge to the pulmonologist and hematologist. We present a rare known case of Au...