Study of Metabolic Syndrome and Thyroid Dysfunction

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Study of Metabolic Syndrome and Thyroid Dysfunction

Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 4

Abstract

Metabolic Syndrome is a group of factors that predispose to cardiovascular diseases. The prevalence of metabolic syndrome is rising rapidly. Recently, a few studies have suggested that thyroid function in the reference range may be associated with metabolic syndrome, but the issue remains unsettled. We aimed to elucidate the relationship between thyroid function and components of metabolic syndrome. Aims: 1. To find out the status of thyroid dysfunction in subjects with metabolic syndrome Methodology: Study was conducted at the N.K.P.Salve Institute of Medical Sciences and Research. It was a hospital-based, cross-sectional study. Seventy patients (n=70) with metabolic syndrome, fulfilling National Cholesterol Education Program (NCEP) Adult Treatment Panel III were subjected to thyroid function tests (fT 3 , fT 4 and TSH) and were included in this study with their consent. A detailed history was taken and clinical examination done. Details like anthropometric measurement of height, weight, waist circumference and systolic and diastolic blood pressure were noted. Fasting blood glucose, triglycerides and HDL-C were estimated in all subjects. Relationship between thyroid function and metabolic syndrome was studied. Diagnosis of the metabolic syndrome was made when 3 or more of the risk determinants were present. Statistical Analysis: Data was expressed as mean ± standard deviation and analyzed by using one-way ANOVA followed by Student's 't' test. Results: ↑ waist circumference in 71.1%, hypertension in 59%, ↑ triglyceride levels in 62%, ↓ HDL-C in 60.8%, impaired fasting glucose in 58%, TSH > 6 mIU/ml in 37%. The metabolic syndrome was present in 54% of the patients. Increased wait circumference was the most common metabolic abnormality in both sexes. Conclusion: Metabolic syndrome was present in 54%, with higher prevalence in females owing increased obesity. Most common abnormality seen was increased waist circumference followed by increased in triglycerides and decrease in HDL-C levels. Prevalence of hypertension was observed to be increasing with age. 37% of patients had increased in TSH levels

Authors and Affiliations

Dr. Nalini R Humaney

Keywords

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EP ID EP211281
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