Study of metronomic chemotherapy in cancer patients at a tertiary care centre in South India
Journal Title: IP Indian Journal of Anatomy and Surgery of Head, Neck and Brain - Year 2018, Vol 4, Issue 2
Abstract
The past century has witnessed a vast progress in the field of cancer chemotherapy Angiogenesis is the foundation of cancer existence Metronomic chemotherapy by definition is the administration of low dose chemotherapy at regular intervals with no longstanding drug free intervals with the aim to achieve continual blood levels of the chemotherapeutic drug without the severe toxicity profile or the longstanding drug free breaks as seen in maximum tolerated dose MTD We conducted a study with the aim to see the role of metronomic chemotherapy in head and cancers at a teritiary care of south IndiaMaterials and Method We did a retrospective analysis of patients diagnosed with cancer of the head and neck who received metronomic chemotherapy in a tertiary cancer care centre for one year A total of 46 patients were included in the study Patients who were at least 18 years old and who had received metronomic chemotherapy for cancer were included in the study The subjective response was assessed based upon the patients symptoms and clinical examination and objective response was assessed using radiological modality wherever available The study was conducted after having been approved by the institution review boardData and Statistical Analysis The Chi Square test was performed to identify the statistical significance between metronomic chemotherapy and the variables analyzed and confidence interval was calculatedResults and Observations In our study we had 46 patients who were diagnosed with head and neck cancer on metronomic chemotherapy and met the criteria and gave informed consent for participation in the study The mean age of patients was 5716 years with 33males and 13females Majority 54 were in stage 4 In this study 74 were symptomatically better 18 got worse 4 were stable and 4 had no change in their symptomatic profileInterpretation and Conclusion In palliative cancer care patients Metronomic chemotherapy is a good option in countries where patients are financially poor where health care facilities are not easily accessible It does not require close monitoring unlike conventional chemotherapy as the side effect profile is lowKeywords Angiogenesis Chemotherapy Metronomic chemotherapy Tumor
Authors and Affiliations
Mohammed Ashraf K. , Nishitha Shetty, R. Arunachalam, Paraashar R. Rai, Arpitha
Keywords
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- EP ID EP489802
- DOI 10.18231/2581-5229.2018.0012
- Views 83
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