Study of Morphological and Cytogenetic Profile of Patients with Acute Myeloid Leukemia in Kashmir Valley
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 6
Abstract
Abstract: Acute myeloid leukemia (AML) is a quickly progressive disease of the myeloid lineage of blood cells. It occurs more commonly in adults than in children, and more commonly in men than women. .While a presumptive diagnosis of AML can be made by examination of the peripheral blood smear when there are circulating leukemic blasts, a definitive diagnosis usually requires an adequate bone marrow aspiration, biopsy and flowcytometry. Cytogenetics study is important in classification of AML and plays an important role in determining the prognosis of the disease. Aim of the study was To study the morphological and cytogenetic profile of AML patients in kashmiri population. This was a retrospective study conducted at Sher-i-Kashmir Institute of Medical Science, Srinagar in the Department of Clinical Hematology on the patients diagnosed as AML patients from January’ 2013 to May’ 2017. The patient data was collected from Regional Cancer Centre. The clinical history, baseline investigations and other specific investigations like bone marrow examination and immunophenotyping was recorded on a preformed proforma. SPSS software was used for statistical analysis. Out of the total 138 cases, 71 were males (51.45 %) & 67 were females (48.55 %) of the total cases. The mean age of presentation in males was 14.2 ± 1.92 and in female was 13±1.82. Leukocytosis was seen in 47.01 % of the total cases in which leucocyte data was available. AML- M2 was the predominant type seen in 45.22 %( 52 out of 115 cases).48 % of total cases (24 out of 50) in which cytogenetics were carried out were with Abnormal Cytogenetics. t(8,21) was seen in 10 out of 24 cases .In 7 cases with AML-M3 morphology , PML RARA test was carried out and it was positive in 5 cases.
Authors and Affiliations
Nusrat Kounsar, Dr. Sajad Geelani, Dr. Subuh Parvez Khan, Dr. Nusrat Bashir, Dr. Syed Mudasir Qadri, Dr. Javid Rasool, Dr. Fiza Parvez Khan
Keywords
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