Study of Neurological Manifestations in Hematolymphoid Neoplasms in A Tertiary Care Hospital In Eastern India
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 8
Abstract
Objectives: In the current study, we proposed to investigate neurological manifestations in patients with hematolymphoid neoplasms in a tertiary care centre in Kolkata Materials and Methods: This was a prospective observational study from 1st February 2013 to 31st January 2015 among newly diagnosed 194 consecutive eligible cases of hematolymphoid neoplasms attending Institute of Hematology and Transfusion Medicine and/or Department of Neurology, Medical College and Hospital, Kolkata. All the patients were subjected to detailed clinical, biochemical, electrophysiological and radiological investigations. Results and Analysis: Overall 22% of total patients of hematolymphoid neoplasms with neurological manifestations had NM at presentation. 28%, 15% & 22% of patients with myeloma, leukemia, and lymphoma respectively had NM at presentation of their HN. Therapy related causes were more (78.8% of patients with neurological manifestations had therapy related complications) than directly disease related causes (28.8%) & indirectly disease related causes (24%). Various neurological manifestations were noted. Most common neurological manifestation in all groups was peripheral neuropathy (40% of total 194 patients). 58.5%, 33.3%, 27.5% of patients with myeloma, leukemia, lymphoma respectively developed neuropathy. Conclusion: Hematolymphoid neoplasms affect both the central and peripheral nervous system and their manifestations can be varied. Most of the patients develop neurological manifestations only during and after therapy. Some patients also have neurological manifestations at presentation and these may be the sole presentation. Therapy leads to more neurological complications than other causes in patients with hematolymphoid neoplasms. Peripheral neuropathy is the commonest neurological manifestation in all groups and shows temporal relationship with therapy.
Authors and Affiliations
Sandip Pal
Keywords
Related Articles
- EP ID EP529847
- DOI -
- Views 72
- Downloads 0
Effect of Coagulation Profile in Third Trimester of Pregnancy
Normal pregnancy associated with many changes in coagulation profile. These changes are important for intrapartum blood loss and also for thromboembolism during pregnancy and labour. The present study aimed at to find ou...
Evaluation of Serum Testosterone Level in Men with Type 2 Diabetes Mellitus
Background: Levels of testosterone and presence of anemia in diabetic males has been in focus over the past decade. Correlation of the testosterone level with anemia in such patients can help in improved diagnosis and ma...
Grade – III ACL Tear with Conservative Physiotherapy –An Evidence Based Study
Introduction: Incidence of ACL injuries have become common conservative management with physiotherapy were recorded with good prognosis Aims and Objectives: The aim of this study was to analyze core strengthening and kin...
Benign, Multicentric, Recurrent and Metastasizing Giant Cell Tumor of Bone: Review of Literature with Role of Immunohistochemistry in Determining Prognosis
Objective: Giant cell tumor (GCT) represents around 4-5% of all primary bone tumors. The purpose of this article is to report this unusual case of benign metastasizing GCT and simultaneously emphasize on the role of immu...
Hypoglycemic Activity of Bridelia Stipularis on Combination of High Fat Diet and STZ Induced Diabetic Rats
The aim of this study is to explore Bridelia stipularis which may lead to discovery of new therapeutic agents which may treat hyperglycemia and in future it may be used in diverse disease condition where hyperglycemia is...