Study of Nitrosative Stress in ‘Pregnancy Induced Hypertension’
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 3
Abstract
Introduction: Hypertension is the most common medical problem encountered during pregnancy. Pregnancy Induced Hypertension (PIH) is also called a disease of maternal endothelium. Nitric-oxide being a potent vasodilator released by endothelial cells, its role has been implicated in PIH. Aim: To study the role of reactive nitrogen species in PIH. Materials and Methods: One hundred and twenty samples were selected for the study. Of these, 60 patients had PIH (case) and the rest without PIH (control). Estimation of serum nitricoxide, serum nitrothiol, serum total thiol was done. Results: The study showed decreased NOx (Mono nitrogen oxide No and No2 ) levels in PIH as compared to control (p< 0.001). PIH patients had significantly higher levels of S-nitrothiols than control (p<0.01). Thiol levels were decreased in PIH as compared to control (p<0.001) Conclusion: Thus, it is concluded from this study that nitrosative stress represents a point of convergence for several contributing factors potentially leading to the clinical manifestations of pregnancy induced hypertension. The antioxidants are used up while scavenging the free radicals.
Authors and Affiliations
Kapila B Gaikwad, Nitin G Joshi, Sohan P Selkar
Keywords
Related Articles
- EP ID EP333955
- DOI 10.7860/JCDR/2017/23960.9396
- Views 96
- Downloads 0
Bardet-Biedl Syndrome Late Diagnosis with a Great Disability: A Case Report
ABSTRACT The Bardet-Biedl Syndrome (BSS) is a genetic disease based on autosomal recessive disorder characterised by non-allelic heterogeneity. The prevalence in the European population is only 1 in 160,000 live births....
Attitudes of Mashhad Public Hospital's Nurses and Midwives toward the Causes and Rates of Medical Errors Reporting
Introduction: Patient’s safety is one of the main objective in healthcare services; however medical errors are a prevalent potential occurrence for the patients in treatment systems. Medical errors lead to an increase in...
Awareness of Breast Cancer and Its Screening among Indonesian Women
ABSTRACT Introduction: Breast cancer has a high morbidity and mortality rate worldwide. However, most developing countries with resource constrained setting, like Indonesia, encounter several difficulties to implement ma...
Rigid Bronchoscopy and Jet Ventilation in Foreign Body Aspiration in A Two-Year-Old Female: A Case Report
ABSTRACT Foreign body aspiration is a leading cause of mortality in children of age group 1-3 years and presents significant challenges to the anaesthesiologist in maintaining oxygenation and ventilation while there is i...
Significance of Blood Eosinophil Count in Patients with Chronic Rhinosinusitis with Nasal Polyposis
Introduction: Chronic Rhino Sinusitis (CRS) is one of the most prevalent chronic illnesses across the globe, affecting persons of all ages. It is an inflammatory process that involves the paranasal sinuses with symptoms...