Study of oxidative stress and hsCRP in alcoholic and nonalcoholic fatty liver disorders
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 2
Abstract
Abstract: Alcoholic and nonalcoholic fatty liver disease is a very common global problem, in worldwide. During oxidative stress the pathological changes observed in AFLD and NAFLD. High CRP levels may put the patients, at increased risk for liver disease. The aim of this study was estimation of oxidative stress and hsCRP in pateint with alcoholic and nonalcoholic fatty liver disease. In the present study, total (n = 495) subjects were recruited for the study and divided in three groups. Group I; (n = 167) of alcoholic liver disease; (n = 158) of nonalcoholic fatty liver disease, and group III included (n = 170) healthy control subjects. HsCRP was measurement of immunoterbidy method. Plasma MDA and Blood activity of SOD, CAT were estimated by spectrophotometric method. The present study shown that levels of MDA and hsCRP was significantly increased (p<0.001) and blood SOD, CAT activity, and were significantly decreased (p<0.001) in AFLD patients as compared with healthy controls, and also significantly increased (p <0.001) and decreased in NFALD patients when they compared with healthy controls. Serum HsCRP and oxidative stress markers are the increased risk for liver disease.
Authors and Affiliations
Haresingh Makwane, Meena Varma, Rajesh Kumar Jha
Keywords
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