Study of oxidative stress and lipid profile in hypothyroid patients
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2017, Vol 3, Issue 3
Abstract
The incidence of hypothyroidism in India is high and it is not adequately controlled. The pathogenesis of hypothyroidism is not very clear, however increased oxidative stress have been reported. Pathological consequences of hypothyroidism point to a high potential for antioxidant imbalance. The present study was carried out to evaluate oxidative stress (MDA, Vitamin C) and to correlate these parameters with the disease process. A total number of 80 subjects comprising of 30 healthy controls and 50 cases studied. Out of 50 patients with hypothyroidism, 30 were subclinical hypothyroid patients and 20 were overt hypothyroid patients. In all the subjects, serum levels of malondialdehyde (MDA) and serum vitamin C were estimated. Serum MDA was significantly increased in overthypothyroidism in comparison to subclinical hypothyroidism and control. The antioxidant serum vitamin C was significantly decreased in overt hypothyroidism when compared to subclinical hypothyroidism and controls. MDA and vitamin c levels correlated with lipid profile explaining the contributory role of oxidative stress and dyslipidemia for the disease process. MDA and serum vitamin C level showed a negative correlation. The presence of increased systemic oxidative stress in hypothyroidism seems to be associated with severity of disease.
Authors and Affiliations
Sanjay Kumar Varun K K Kshitiz
Keywords
Related Articles
- EP ID EP550078
- DOI 10.22192/ijcrms.2017.03.03.007
- Views 120
- Downloads 0
A rare case report of mixed uterine cancer with two distinct histological types: a spectrum of endometrioid adenocarcinoma with transitional cell carcinoma
Introduction: Endometrioid adenocarcinoma of the uterine corpus can coexist with squamous cell carcinoma, serous or clear cell adenocarcinoma and sarcoma. There are only 14 cases of pure transitional cell carcinoma of ut...
Sonographic findings in patients with upper abdominal pain in Nnewi community, Anambra state, Nigeria.
Abdominal ultrasound is a rapid and non-invasive method of examination of the abdomen. Abdominal ultrasound is an imaging procedure used to examine the internal organs of the abdomen including the liver, gallbladder, spl...
Antibacterial activity of some Holy Plants
Medicinal plants are being used from earliest without knowing about their active elements. Herbs are occupied the top source of novel drug with antimicrobial activity. With reference to these points, the ethanolic extrac...
Knowledge, Attitude and Practice (KAP) on Diabetic Retinopathy among diabetic Patients living in hilly areas of Lumbini Zone of Nepal
Introduction: Diabetes Mellitus (DM) is a metabolic disorder which is characterized by elevated blood sugar levels. It is a non-communicable disease and currently one of the major causes for avoidable blindness globally....
Pattern of oral lesions – Cytohistopathological study in tertiary care centre.
The prevalence and incidence of oral lesions are uncommon. Many of these lesions can be identified as specific entities on the basis of their histopathological features and are divided into epithelial, fibrous, vascular...