STUDY OF PATTERN REVERSAL VISUAL EVOKED POTENTIAL (PR-VEP) IN PRIMARY OPEN ANGLE GLAUCOMA
Journal Title: International Journal of Basic and Applied Physiology - Year 2015, Vol 4, Issue 1
Abstract
Background & Objectives: Glaucoma is characterized by an optic neuropathy, often associated with elevated intra occular pressure (IOP) leading to characteristic visual field defects and optic nerve head damage. Elevation of intraocular IOP is believed to cause pressure on the retinal nerve fibers bundles as they course into the optic nerve which alters the VEP waveforms. Pattern VEP has been shown to be sensitive to glaucomatous optic neuropathy since they are compatible with the functions of retinal ganglion cells. Aim of study is to compare pattern VEP in patients with POAG and in healthy controls to assess the utility of VEP in detecting cases of glaucoma. Methods: Study was done in 60 subjects (120 eyes). Group1: POAG (30 patients) & Group2: Controls (30 subjects). All underwent PR VEP investigation in the Dept. of Physiology, Govt.medical college,Bhavnagar. Latency and amplitude of N75, P100, N145 were recorded. Visual fields were assessed at Ophthalmology dept. Sir T hospital, Bhavnagar. The differences of PRVEP parameters among POAG and control groups were compared. Results: N75, P100, N145 latency was prolonged in all 60 eyes(100%) and P100-N75 amplitude was reduced in 56 eyes (93.33%) in group1. The Mean Deviation (MD) values and sLV in the POAG patients were negatively correlated with the latency time of P100. POAG has been found to affect the PR-VEP by causing both the reductions in P100 amplitude and increments in all latencies when compared with that of the control group. Interpretation and Conclusion: Our study advocates the use of PRVEP as an objective electrophysiological tool for detecting optic nerve pathology in POAG, because increase in latency times are significantly associated with optic nerve damage.
Authors and Affiliations
Purva Hathila, Chintan Damor, M. Shanishchara, H. B. Mehta, Nilesh Parekh
Keywords
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